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新型冠状病毒肺炎传播的数学模型、预测与分析

Mathematical model, forecast and analysis on the spread of COVID-19.

作者信息

Mishra Bimal Kumar, Keshri Ajit Kumar, Saini Dinesh Kumar, Ayesha Syeda, Mishra Binay Kumar, Rao Yerra Shankar

机构信息

Principal, Markham College of Commerce, Hazaribag, India.

Department of Computer Science & Engineering, Birla Institute of Technology, Mesra, Ranchi, India.

出版信息

Chaos Solitons Fractals. 2021 Jun;147:110995. doi: 10.1016/j.chaos.2021.110995. Epub 2021 Apr 27.

Abstract

Pandemic COVID-19 which has infected more than 35,027,546 people and death more than 1,034,837 people in 235 countries as on October 05, 2020 has created a chaos across the globe. In this paper, we develop a compartmental epidemic model to understand the spreading behaviour of the disease in human population with a special case of Bhilwara, a desert town in India where successful control measures TTT (tracking, testing and treatment) was adopted to curb the disease in the very early phase of the spread of the disease in India. Local and global asymptotic stability is established for endemic equilibrium. Extensive numerical simulations with real parametric values are performed to validate the analytical results. Trend analysis of fatality rate, infection rate, and impact of lockdown is performed for USA, European countries, Russia, Iran, China, Japan, S. Korea with a comparative assessment by India. Kruskal - Wallis test is performed to test the null hypothesis for infected cases during the four lockdown phases in India. It has been observed that there is a significant difference at both 95% and 99% confidence interval in the infected cases, recovered cases and the case fatality rate during all the four phases of the lockdown.

摘要

截至2020年10月5日,全球235个国家的新冠大流行已感染超过35027546人,死亡超过1034837人,在全球造成了混乱。在本文中,我们建立了一个分区流行病模型,以了解该疾病在人群中的传播行为,特别以印度沙漠城镇比尔瓦拉为例,在印度疾病传播的早期阶段,当地成功采取了追踪、检测和治疗(TTT)控制措施来遏制疾病。我们建立了地方病平衡点的局部和全局渐近稳定性。利用实际参数值进行了广泛的数值模拟,以验证分析结果。对美国、欧洲国家、俄罗斯、伊朗、中国、日本、韩国的死亡率、感染率和封锁影响进行了趋势分析,并与印度进行了比较评估。进行了克鲁斯卡尔-沃利斯检验,以检验印度四个封锁阶段感染病例的零假设。据观察,在封锁的所有四个阶段,感染病例、康复病例和病死率在95%和99%置信区间均存在显著差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bda/8079075/11327715da91/gr1_lrg.jpg

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