Elfil Mohamed, Selby Laura, Van Schooneveld Trevor C, Fadul Nada
Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Division of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
IDCases. 2021;24:e01140. doi: 10.1016/j.idcr.2021.e01140. Epub 2021 Apr 27.
The COVID-19 pandemic has created overwhelming circumstances not only in the medical field, but in other walks of life. SARS-CoV-2, the causative virus of COVID-19 [1], primarily affects the respiratory system leading to respiratory illnesses of varying severity ranging from mild flu-like symptoms to acute respiratory distress syndrome [2]. However, the clinical manifestations of COVID-19 are not limited to the respiratory system [3]. There is a growing body of literature showing the incidence of a varying clinical spectrum of neuropsychiatric manifestations in a significant proportion of COVID-19 patients [4]. With the variability in neuropsychiatric presentation of COVID- 19, multiple mechanisms have been proposed to explain the pathophysiology of these presentations [5]. In this case report, we present a 20-year-old female with no significant respiratory symptoms or previous history of psychotic episodes who manifested with acute psychosis as a significant complication of COVID-19.
新冠疫情不仅给医学领域带来了巨大压力,也给其他各行各业带来了难以承受的局面。严重急性呼吸综合征冠状病毒2(SARS-CoV-2)是新冠病毒病(COVID-19)的致病病毒[1],主要影响呼吸系统,导致从轻微流感样症状到急性呼吸窘迫综合征等不同严重程度的呼吸道疾病[2]。然而,COVID-19的临床表现并不局限于呼吸系统[3]。越来越多的文献表明,相当一部分COVID-19患者出现了不同临床谱的神经精神症状[4]。鉴于COVID-19神经精神症状表现的多样性,人们提出了多种机制来解释这些表现的病理生理学[5]。在本病例报告中,我们介绍了一名20岁女性,她没有明显的呼吸道症状,也没有精神病史,却出现了急性精神病,这是COVID-19的一种严重并发症。