State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China; School of Applied Chemical Engineering, University of Science and Technology of China, Road Baohe District, Hefei, Anhui, 230026, PR China.
Department of Radiology, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, 130033, PR China.
Biomaterials. 2021 Jul;274:120821. doi: 10.1016/j.biomaterials.2021.120821. Epub 2021 Apr 27.
Facile fabrication of Fe-based nanotheranostic agents with the enhanced Chemodynamic therapy (CDT) effect and multiple functions is important for oncotherapy. In this report, noble-metal@FeO core-shell nanoparticles (Au@FeO NPs, AuRu@FeO NPs, AuPt@FeO NPs and AuPd@FeO NPs) are one-pot constructed by a simply redox self-assembly strategy. As a typical example, AuPd@FeO NPs are applied for oncotherapy. Compared to their crystalline counterparts (e.g., AuPd@c-FeO nanocrystals (NCs)), AuPd@FeO NPs with the metastable FeO shell can be activated by a small amount of NaBH to obviously enhance the production of ·OH in subsequent Fenton reaction (these activated products are termed as r-AuPd@FeO NPs). In addition, a favorable photothermal effect (63.5% photothermal conversion efficiency) of r-AuPd@FeO NPs can further promote the ·OH generation. Moreover, r-AuPd@FeO NPs also show a pH-responsive T-weighted MRI contrast property, CT imaging capacity and the function of regulating tumor microenvironment. This work presents an attractive route to prepare versatile nanotheranostic agents.
制备具有增强化学动力学治疗（CDT）效果和多功能的基于铁的纳米诊疗剂对于肿瘤治疗非常重要。在本报告中，通过简单的氧化还原自组装策略一锅法构建了贵金属@FeO 核壳纳米粒子（Au@FeO NPs、AuRu@FeO NPs、AuPt@FeO NPs 和 AuPd@FeO NPs）。以 AuPd@FeO NPs 作为典型例子用于肿瘤治疗。与它们的晶态对应物（例如，AuPd@c-FeO 纳米晶体（NCs））相比，具有亚稳态 FeO 壳的 AuPd@FeO NPs 可以被少量的 NaBH 激活，从而明显增强随后的芬顿反应中·OH 的产生（这些被激活的产物被称为 r-AuPd@FeO NPs）。此外，r-AuPd@FeO NPs 的良好光热效应（63.5%的光热转换效率）可以进一步促进·OH 的产生。此外，r-AuPd@FeO NPs 还表现出 pH 响应的 T 加权 MRI 对比性能、CT 成像能力以及调节肿瘤微环境的功能。这项工作为制备多功能纳米诊疗剂提供了一种有吸引力的途径。
