Institute of Bioengineering, School of Life Sciences and School of Engineering, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Nat Rev Genet. 2021 Aug;22(8):518-531. doi: 10.1038/s41576-021-00355-7. Epub 2021 May 10.
The temporal coordination of events at cellular and tissue scales is essential for the proper development of organisms, and involves cell-intrinsic processes that can be coupled by local cellular signalling and instructed by global signalling, thereby creating spatial patterns of cellular states that change over time. The timing and structure of these patterns determine how an organism develops. Traditional developmental genetic methods have revealed the complex molecular circuits regulating these processes but are limited in their ability to predict and understand the emergent spatio-temporal dynamics. Increasingly, approaches from physics are now being used to help capture the dynamics of the system by providing simplified, generic descriptions. Combined with advances in imaging and computational power, such approaches aim to provide insight into timing and patterning in developing systems.
细胞和组织层面事件的时间协调对于生物体的正常发育至关重要，涉及细胞内在的过程，可以通过局部细胞信号进行耦合，并受全局信号的指导，从而创建随时间变化的细胞状态的空间模式。这些模式的时间和结构决定了生物体如何发育。传统的发育遗传方法已经揭示了调节这些过程的复杂分子电路，但它们在预测和理解新兴的时空动态方面的能力有限。现在，越来越多的物理学方法正被用于通过提供简化的、通用的描述来帮助捕捉系统的动态。结合成像和计算能力的进步，这些方法旨在深入了解发育系统中的时间和模式。
