Department of Nephrology, The First Affiliated Hospital of China Medical University, Shenyang, 110000 Liaoning Province, China.
Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000 Sichuan Province, China.
Oxid Med Cell Longev. 2021 May 3;2021:6654887. doi: 10.1155/2021/6654887. eCollection 2021.
Acute and chronic kidney injuries result from structural dysfunction and metabolic disorders of the kidney in various etiologies, which significantly affect human survival and social wealth. Nephropathies are often accompanied by various forms of cell death and complex microenvironments. In recent decades, the study of kidney diseases and the traditional forms of cell death have improved. Nontraditional forms of cell death, represented by ferroptosis and necroptosis, have been discovered in the field of kidney diseases, which have reshuffled the role of traditional cell death in nephropathies. Although interactions between ferroptosis and acute kidney injury (AKI) have been continuously explored, studies on ferroptosis and chronic kidney disease (CKD) remain limited. Here, we have reviewed the therapeutic significance of ferroptosis in AKI and anticipated the curative potential of ferroptosis for CKD in the hope of providing insights into ferroptosis and CKD.
急性和慢性肾损伤是由各种病因引起的肾脏结构功能和代谢紊乱导致的，这严重影响了人类的生存和社会财富。肾病常伴有多种形式的细胞死亡和复杂的微环境。近几十年来，肾脏病和传统细胞死亡形式的研究得到了改善。在肾脏病领域发现了以铁死亡和坏死性凋亡为代表的非传统细胞死亡形式，这重新排列了传统细胞死亡在肾脏病中的作用。尽管铁死亡与急性肾损伤（AKI）之间的相互作用不断被探索，但铁死亡与慢性肾脏病（CKD）的研究仍然有限。在这里，我们回顾了铁死亡在 AKI 中的治疗意义，并预测了铁死亡对 CKD 的治疗潜力，希望能为铁死亡和 CKD 提供一些见解。
