Glupczynski Y, Delmee M, Bruck C, Labbe M, Avesani V, Burette A
Department of Microbiology, Brugmann University Hospital, Brussels, Belgium.
Eur J Epidemiol. 1988 Jun;4(2):154-7. doi: 10.1007/BF00144743.
Forty-nine isolates of Campylobacter pylori were tested for their susceptibility to twenty antibiotics and four anti-ulcer agents by an agar dilution technique. Penicillin and amoxycillin were the most active drugs (MIC90, 0.06 microgram/ml); erythromycin, cefazolin, minocycline, ciprofloxacin, ofloxacin and gentamicin were slightly less active (MIC90, less than or equal to 1 microgram/ml). Moderate activity was found for doxycyclin, rifampin, nitrofurantoin, norfloxacin, pefloxacin, enoxacin, paromomycin, metronidazole and tinidazole. All strains were resistant to trimethoprim (MIC greater than 512 micrograms/ml). Nalidixic acid (MIC90, greater than 256 micrograms/ml) and colistin (MIC90, greater than 64 micrograms/ml) had little to no activity. Of four anti-ulcer drugs, only bismuth subcitrate showed activity (MIC90, 64 micrograms/ml). Strains resistant to all 4-quinolones were found in patients who had previously received ofloxacin as part of a clinical trial aimed at eradication of C. pylori. These isolates remained susceptible to amoxycillin, tetracyclines and to other classes of antibiotics.
采用琼脂稀释法对49株幽门螺杆菌进行了20种抗生素和4种抗溃疡药物的敏感性测试。青霉素和阿莫西林是活性最强的药物（MIC90为0.06微克/毫升）；红霉素、头孢唑林、米诺环素、环丙沙星、氧氟沙星和庆大霉素的活性稍低（MIC90小于或等于1微克/毫升）。强力霉素、利福平、呋喃妥因、诺氟沙星、培氟沙星、依诺沙星、巴龙霉素、甲硝唑和替硝唑有中等活性。所有菌株对甲氧苄啶耐药（MIC大于512微克/毫升）。萘啶酸（MIC90大于256微克/毫升）和黏菌素（MIC90大于64微克/毫升）几乎没有活性。4种抗溃疡药物中，只有枸橼酸铋钾有活性（MIC90为64微克/毫升）。在先前接受氧氟沙星作为根除幽门螺杆菌临床试验一部分的患者中发现了对所有4-喹诺酮类耐药的菌株。这些分离株对阿莫西林、四环素和其他类抗生素仍敏感。
