University of Illinois at Urbana-Champaign, Department of Microbiology, Urbana, IL, 61801, USA.
Trends Microbiol. 2021 Dec;29(12):1117-1129. doi: 10.1016/j.tim.2021.04.008. Epub 2021 May 21.
The phages that infect Staphylococcus species are dominant residents of the skin microbiome that play critical roles in health and disease. While temperate phages, which can integrate into the host genome, have the potential to promote staphylococcal pathogenesis, the strictly lytic variety are powerful antimicrobials that are being exploited for therapeutic applications. This article reviews recent insights into the diversity of staphylococcal phages and newly described mechanisms by which they influence host pathogenicity. The latest efforts to harness these viruses to eradicate staphylococcal infections are also highlighted. Decades of research has focused on the temperate phages of Staphylococcus aureus as model systems, thus underscoring the need to broaden basic research efforts to include diverse phages that infect other clinically relevant Staphylococcus species.
感染葡萄球菌的噬菌体是皮肤微生物组中的主要居民，在健康和疾病中发挥着关键作用。虽然能够整合到宿主基因组中的温和噬菌体有可能促进葡萄球菌的发病机制，但严格的裂解噬菌体是强大的抗菌药物，正被用于治疗应用。本文综述了最近对葡萄球菌噬菌体多样性的研究进展，以及它们影响宿主致病性的新描述的机制。还强调了利用这些病毒根除葡萄球菌感染的最新努力。几十年来，研究一直集中在金黄色葡萄球菌的温和噬菌体作为模型系统，因此强调需要扩大基础研究工作，包括感染其他临床相关葡萄球菌的不同噬菌体。
