Tekirdağ Namık Kemal University, Scientific and Technological Research Center, Tekirdağ, Turkey.
Tekirdağ Namık Kemal University, Scientific and Technological Research Center, Tekirdağ, Turkey.
Adv Clin Chem. 2021;102:1-62. doi: 10.1016/bs.acc.2020.08.001. Epub 2020 Sep 14.
In recent years, advances in immunosensor device fabrication have significantly expanded the use of this technology in a broad range of applications including clinical diagnosis, food analysis, quality control, environmental studies and industrial monitoring. The most important aspect in fabrication is to obtain a design that provides a low detection limit. The utilization of nanomaterials as a label, catalyst and biosensing transducer is, perhaps, the most popular approach in ultrasensitive devices. This chapter reviews recent advances in immunosensor fabrication and summarizes the most recent studies. Strategies employed to significantly improve sensitivity and specificity of immunosensor technology and the advantages and limitations thereof are explored.
近年来，免疫传感器器件制造方面的进展显著扩展了该技术在广泛应用领域的应用，包括临床诊断、食品分析、质量控制、环境研究和工业监测。制造过程中最重要的方面是获得提供低检测限的设计。纳米材料作为标记物、催化剂和生物传感器换能器的应用可能是超灵敏器件中最受欢迎的方法。本章综述了免疫传感器制造方面的最新进展，并总结了最近的研究。探讨了用于显著提高免疫传感器技术的灵敏度和特异性的策略及其优缺点。
