Suppr超能文献

如不加以缓解,疗养院中的疫情爆发可能会导致严重的疾病负担。

Outbreaks in care homes may lead to substantial disease burden if not mitigated.

机构信息

Department of Mathematics, University of Manchester, Manchester, UK.

The Alan Turing Institute, London, UK.

出版信息

Philos Trans R Soc Lond B Biol Sci. 2021 Jul 19;376(1829):20200269. doi: 10.1098/rstb.2020.0269. Epub 2021 May 31.

Abstract

The number of COVID-19 outbreaks reported in UK care homes rose rapidly in early March of 2020. Owing to the increased co-morbidities and therefore worse COVID-19 outcomes for care home residents, it is important that we understand this increase and its future implications. We demonstrate the use of an SIS model where each nursing home is an infective unit capable of either being susceptible to an outbreak (S) or in an active outbreak (I). We use a generalized additive model to approximate the trend in growth rate of outbreaks in care homes and find the fit to be improved in a model where the growth rate is proportional to the number of current care home outbreaks compared with a model with a constant growth rate. Using parameters found from the outbreak-dependent growth rate, we predict a 73% prevalence of outbreaks in UK care homes without intervention as a reasonable worst-case planning assumption. This article is part of the theme issue 'Modelling that shaped the early COVID-19 pandemic response in the UK'.

摘要

2020 年 3 月初,英国养老院报告的 COVID-19 疫情迅速增加。由于养老院居民的合并症增加,因此 COVID-19 结果更差,因此了解这种增加及其未来影响非常重要。我们展示了使用 SIS 模型的情况,在该模型中,每个疗养院都是一个具有传染性的单位,要么容易受到疫情爆发(S)的影响,要么处于疫情爆发(I)中。我们使用广义加性模型来近似养老院疫情增长率的趋势,并发现与具有恒定增长率的模型相比,将增长率与当前养老院疫情数量成正比的模型拟合度得到改善。使用从疫情相关增长率中找到的参数,我们预测如果不进行干预,英国养老院的疫情流行率将达到 73%,这是一个合理的最坏情况规划假设。本文是“塑造英国 COVID-19 大流行早期应对措施的建模”专题的一部分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56b9/8165603/a4c3053f5865/rstb20200269f01.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验