Vedhanayagam Mohan, Raja Iruthayapandi Selestin, Molkenova Anara, Atabaev Timur Sh, Sreeram Kalarical Janardhanan, Han Dong-Wook
CATERS Laboratory, CSIR-Central Leather Research Institute, Adyar, Chennai 600020, India.
BIO-IT Fusion Technology Research Institute, Pusan National University, Busan 46241, Korea.
Int J Mol Sci. 2021 May 20;22(10):5378. doi: 10.3390/ijms22105378.
Regeneration of damaged tissues or organs is one of the significant challenges in tissue engineering and regenerative medicine. Many researchers have fabricated various scaffolds to accelerate the tissue regeneration process. However, most of the scaffolds are limited in clinical trials due to scaffold inconsistency, non-biodegradability, and lack of non-invasive techniques to monitor tissue regeneration after implantation. Recently, carbon dots (CDs) mediated fluorescent scaffolds are widely explored for the application of image-guided tissue engineering due to their controlled architecture, light-emitting ability, higher chemical and photostability, excellent biocompatibility, and biodegradability. In this review, we provide an overview of the recent advancement of CDs in terms of their different synthesis methods, tunable physicochemical, mechanical, and optical properties, and their application in tissue engineering. Finally, this review concludes the further research directions that can be explored to apply CDs in tissue engineering.
受损组织或器官的再生是组织工程和再生医学中的重大挑战之一。许多研究人员制造了各种支架来加速组织再生过程。然而，由于支架的不一致性、不可生物降解性以及缺乏植入后监测组织再生的非侵入性技术，大多数支架在临床试验中受到限制。近年来，碳点（CDs）介导的荧光支架因其可控的结构、发光能力、较高的化学和光稳定性、优异的生物相容性和生物降解性，被广泛用于图像引导组织工程的应用。在这篇综述中，我们概述了碳点在不同合成方法、可调的物理化学、机械和光学性质以及它们在组织工程中的应用方面的最新进展。最后，本综述总结了在组织工程中应用碳点可探索的进一步研究方向。
