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利用生物法制备的氧化镁纳米颗粒（Mg-NPs）控制病原微生物和疟疾病媒的环保方法。

An Eco-Friendly Approach to the Control of Pathogenic Microbes and Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by .

机构信息

Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, Egypt.

Department of Zoology and Entomology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, Egypt.

出版信息

Int J Mol Sci. 2021 May 12;22(10):5096. doi: 10.3390/ijms22105096.

DOI:10.3390/ijms22105096
PMID:34065835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8151347/
Abstract

The discovery of eco-friendly, rapid, and cost-effective compounds to control diseases caused by microbes and insects are the main challenges. Herein, the magnesium oxide nanoparticles (MgO-NPs) are successfully fabricated by harnessing the metabolites secreted by . The fabricated MgO-NPs were characterized using UV-Vis, XRD, TEM, DLS, EDX, FT-IR, and XPS analyses. Data showed the successful formation of crystallographic, spherical, well-dispersed MgO-NPs with sizes of 7-40 nm at a maximum wavelength of 250 nm. The EDX analysis confirms the presence of Mg and O ions as the main components with weight percentages of 13.62% and 7.76%, respectively. The activity of MgO-NPs as an antimicrobial agent was investigated against pathogens , , , , and , and exhibited zone of inhibitions of 12.0 ± 0.0, 12.7 ± 0.9, 23.3 ± 0.8, 17.7 ± 1.6, and 14.7 ± 0.6 mm respectively, at 200 µg mL. The activity is decreased by decreasing the MgO-NPs concentration. The biogenic MgO-NPs exhibit high efficacy against different larvae instar and pupa of , with LC50 values of 12.5-15.5 ppm for I-IV larvae instar and 16.5 ppm for the pupa. Additionally, 5 mg/cm of MgO-NPs showed the highest protection percentages against adults of , with values of 100% for 150 min and 67.6% ± 1.4% for 210 min.

摘要

发现对微生物和昆虫引起的疾病具有环保、快速和经济高效的化合物是主要挑战。在此，通过利用分泌的代谢产物成功制备了氧化镁纳米粒子（MgO-NPs）。利用 UV-Vis、XRD、TEM、DLS、EDX、FT-IR 和 XPS 分析对制备的 MgO-NPs 进行了表征。数据显示，成功地形成了具有最大波长为 250nm 的结晶、球形、分散良好的 MgO-NPs，粒径为 7-40nm。EDX 分析证实了 Mg 和 O 离子的存在，它们是主要成分，重量百分比分别为 13.62%和 7.76%。MgO-NPs 作为一种抗菌剂的活性针对病原体 、 、 、 、 和 进行了研究，在 200µg mL 时分别表现出 12.0±0.0、12.7±0.9、23.3±0.8、17.7±1.6 和 14.7±0.6mm 的抑菌圈。活性随 MgO-NPs 浓度的降低而降低。生物成因的 MgO-NPs 对 不同幼虫龄期和蛹期的 表现出很高的功效，LC50 值分别为 12.5-15.5ppm 的 I-IV 幼虫龄期和 16.5ppm 的蛹期。此外，5mg/cm 的 MgO-NPs 对 成虫的保护率最高，在 150min 时达到 100%，在 210min 时达到 67.6%±1.4%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b0/8151347/40580305a45b/ijms-22-05096-g006.jpg
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