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HFY01发酵豆浆对D-半乳糖诱导的早衰小鼠模型的抗氧化作用

Antioxidant Effect of Soymilk Fermented by HFY01 on D-Galactose-Induced Premature Aging Mouse Model.

作者信息

Li Chong, Fan Yang, Li Shuang, Zhou Xianrong, Park Kun-Young, Zhao Xin, Liu Huazhi

机构信息

Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing, China.

Chongqing Engineering Research Center of Functional Food, Chongqing University of Education, Chongqing, China.

出版信息

Front Nutr. 2021 May 17;8:667643. doi: 10.3389/fnut.2021.667643. eCollection 2021.

DOI:10.3389/fnut.2021.667643
PMID:34079813
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8165163/
Abstract

The antioxidant effect of soymilk fermented by HFY01 (screened from yak yogurt) was investigated on mice with premature aging induced by D-galactose. antioxidant results showed that HFY01-fermented soymilk (LP-HFY01-DR) had better ability to scavenge the free radicals 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) diammonium salt (ABTS) than unfermented soymilk and -fermented soymilk. Histopathological observation showed that LP-HFY01-DR could protect the skin, spleen and liver, reduce oxidative damage and inflammation. Biochemical results showed that LP-HFY01-DR could effectively upregulate glutathione (), catalase (), superoxide dismutase (), and glutathione peroxidase () levels and decrease malondialdehyde () content in the liver, brain, and serum. Real-time quantitative reverse transcription polymerase chain reaction further showed that LP-HFY01-DR could promote the relative expression levels of the genes encoding for cuprozinc superoxide dismutase (), manganese superoxide dismutase (), , and in the liver, spleen, and skin. High-performance liquid chromatography results revealed daidzin, glycitin, genistin, daidzein, glycitein, and genistein in LP-HFY01-DR. In conclusion, LP-HFY01-DR could improve the antioxidant capacity in mice with premature aging induced by D-galactose.

摘要

研究了由HFY01（从牦牛酸奶中筛选得到）发酵的豆浆对D-半乳糖诱导的早衰小鼠的抗氧化作用。抗氧化结果表明，HFY01发酵豆浆（LP-HFY01-DR）比未发酵豆浆和其他发酵豆浆具有更好的清除1,1-二苯基-2-苦基肼（DPPH）和2,2'-联氮-双-（3-乙基苯并噻唑啉-6-磺酸）二铵盐（ABTS）自由基的能力。组织病理学观察表明，LP-HFY01-DR可以保护皮肤、脾脏和肝脏，减少氧化损伤和炎症。生化结果表明，LP-HFY01-DR可以有效上调肝脏、大脑和血清中的谷胱甘肽（）、过氧化氢酶（）、超氧化物歧化酶（）和谷胱甘肽过氧化物酶（）水平，并降低丙二醛（）含量。实时定量逆转录聚合酶链反应进一步表明，LP-HFY01-DR可以促进肝脏、脾脏和皮肤中编码铜锌超氧化物歧化酶（）、锰超氧化物歧化酶（）、 和 的基因的相对表达水平。高效液相色谱结果显示LP-HFY01-DR中含有大豆苷、黄豆黄素、染料木苷、大豆苷元、黄豆黄素和染料木黄酮。总之，LP-HFY01-DR可以提高D-半乳糖诱导的早衰小鼠的抗氧化能力。

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