State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, People's Republic of China.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Nat Commun. 2021 Jun 7;12(1):3393. doi: 10.1038/s41467-021-23710-y.
The iron gall ink-triggered chemical corrosion of hand-written documents is a big threat to Western cultural heritages, which was demonstrated to result from the iron gall (GA-Fe) chelate-promoted reactive oxygen species generation. Such a phenomenon has inspired us to apply the pro-oxidative mechanism of GA-Fe to anticancer therapy. In this work, we construct a composite cancer nanomedicine by loading gallate into a Fe-engineered mesoporous silica nanocarrier, which can degrade in acidic tumor to release the doped Fe and the loaded gallate, forming GA-Fe nanocomplex in situ. The nanocomplex with a highly reductive ligand field can promote oxygen reduction reactions generating hydrogen peroxide. Moreover, the resultant two-electron oxidation form of GA-Fe is an excellent Fenton-like agent that can catalyze hydrogen peroxide decomposition into hydroxyl radical, finally triggering severe oxidative damage to tumors. Such a therapeutic approach by intratumoral synthesis of GA-Fe nano-metalchelate may be instructive to future anticancer researches.
铁胆墨水引发的手写文档化学腐蚀对西方文化遗产是一个巨大的威胁，这是由于铁胆（GA-Fe）配合物促进活性氧物种的产生所致。这种现象启发我们将 GA-Fe 的促氧化机制应用于癌症治疗。在这项工作中，我们通过将没食子酸负载到铁工程介孔硅纳米载体中构建了一种复合癌症纳米药物，该载体在酸性肿瘤中可降解以释放掺杂的 Fe 和负载的没食子酸，从而在原位形成 GA-Fe 纳米复合物。具有高还原配体场的纳米复合物可促进氧还原反应生成过氧化氢。此外，GA-Fe 的二价氧化形式是一种出色的类 Fenton 试剂，可催化过氧化氢分解为羟基自由基，最终引发肿瘤的严重氧化损伤。这种通过肿瘤内合成 GA-Fe 纳米金属配合物的治疗方法可能对未来的癌症研究具有指导意义。
