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1
Polynucleotides. L. Synthesis and properties of poly (2'-chloro-2'-deoxyadenylic acid) and poly (2'-bromo-2'-deoxyadenylic acid).多核苷酸。L.聚（2'-氯-2'-脱氧腺苷酸）和聚（2'-溴-2'-脱氧腺苷酸）的合成及性质
Nucleic Acids Res. 1977 Dec;4(12):4249-60. doi: 10.1093/nar/4.12.4249.
2
Polynucleotides. XL. Synthesis and properties of poly 2'-azido-2'-deoxyadenylic acid.多核苷酸。XL。聚2'-叠氮基-2'-脱氧腺苷酸的合成及性质
Nucleic Acids Res. 1976 Aug;3(8):2089-99. doi: 10.1093/nar/3.8.2089.
3
Polynucleotides. LII. Synthesis and properties of poly(2'-deoxy-2'-fluoroadenylic acid).多核苷酸。LII。聚（2'-脱氧-2'-氟腺苷酸）的合成与性质
Nucleic Acids Res. 1978 Jun;5(6):1877-87. doi: 10.1093/nar/5.6.1877.
4
Polynucleotides. XLV Synthesis and properties of poly(2'-azido-2'-deoxyinosinic acid).多核苷酸。XLV. 聚（2'-叠氮基-2'-脱氧肌苷酸）的合成与性质
Nucleic Acids Res. 1977 Aug;4(8):2629-39. doi: 10.1093/nar/4.8.2629.
5
Polynucleotides. XLVI. 1 Synthesis and properties of poly (2'-amino-2'-deoxyadenylic acid).多核苷酸。XLVI。1. 聚（2'-氨基-2'-脱氧腺苷酸）的合成与性质
Nucleic Acids Res. 1977 Apr;4(4):989-1000. doi: 10.1093/nar/4.4.989.
6
Polynucleotides. LVII. Synthesis and properties of poly (2'-chloro-2'-deoxyinosinic acid).多核苷酸。LVII。聚（2'-氯-2'-脱氧肌苷酸）的合成与性质
Nucleic Acids Res. 1979 Jun 11;6(7):2627-36. doi: 10.1093/nar/6.7.2627.
7
Poly(8-bromo-2'-deoxyadenylic acid): the syn/anti relationship.聚（8-溴-2'-脱氧腺苷酸）：顺式/反式关系。
Biochim Biophys Acta. 1984 Aug 21;800(3):207-13. doi: 10.1016/0304-4165(84)90397-0.
8
Polynucleotides. XXVI. Complex formation of polynucleotides derived from formycin and laurusin with cyclonucleoside oligonucleotides.多核苷酸。二十六。源自间型霉素和月桂霉素的多核苷酸与环核苷寡核苷酸的复合物形成
Nucleic Acids Res. 1974 Jul;1(7):907-17. doi: 10.1093/nar/1.7.907.
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Protein synthesis using poly(2'-halogeno-2'-deoxyadenylic acids) as messenger.以聚（2'-卤代-2'-脱氧腺苷酸）为信使进行蛋白质合成。
Biochim Biophys Acta. 1982 May 31;697(2):174-7. doi: 10.1016/0167-4781(82)90074-4.
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Polynucleotides. XLIV. Synthesis and properties of poly (2-azaadenylic acid) and poly(2-azainosinic acid).多核苷酸。XLIV。聚（2-氮杂腺苷酸）和聚（2-氮杂肌苷酸）的合成及性质
Biochim Biophys Acta. 1978 Sep 27;520(2):441-51. doi: 10.1016/0005-2787(78)90241-1.

引用本文的文献

1
Structural requirements of polynucleotides for the activation of (2' - 5')An polymerase and protein kinase.多核苷酸激活(2'-5')聚腺苷酸聚合酶和蛋白激酶的结构要求。
Nucleic Acids Res. 1981 Oct 10;9(19):4939-50. doi: 10.1093/nar/9.19.4939.
2
Polynucleotides. LVI. Synthesis and properties of poly(2-deoxy-2'-fluoroinosinic acid).多核苷酸。LVI。聚（2-脱氧-2'-氟肌苷酸）的合成与性质
Nucleic Acids Res. 1978 Sep;5(9):3315-24. doi: 10.1093/nar/5.9.3315.
3
Polynucleotides. LII. Synthesis and properties of poly(2'-deoxy-2'-fluoroadenylic acid).多核苷酸。LII。聚（2'-脱氧-2'-氟腺苷酸）的合成与性质
Nucleic Acids Res. 1978 Jun;5(6):1877-87. doi: 10.1093/nar/5.6.1877.
4
Polynucleotides. LVII. Synthesis and properties of poly (2'-chloro-2'-deoxyinosinic acid).多核苷酸。LVII。聚（2'-氯-2'-脱氧肌苷酸）的合成与性质
Nucleic Acids Res. 1979 Jun 11;6(7):2627-36. doi: 10.1093/nar/6.7.2627.

本文引用的文献

1
[POLYNUCLEOTIDE PHOSPHORYLASE PURIFIED FROM ESCHERICHIA COLI].[从大肠杆菌中纯化的多核苷酸磷酸化酶]
Biochim Biophys Acta. 1964 Jul 8;89:66-89.
2
The molecular structure of polyadenylic acid.聚腺苷酸的分子结构。
J Mol Biol. 1961 Feb;3:71-86. doi: 10.1016/s0022-2836(61)80009-0.
3
Calculation of the optical rotatory dispersion of dinucleoside phosphates.二核苷磷酸光学旋转色散的计算
J Mol Biol. 1967 Feb 14;23(3):601-4. doi: 10.1016/s0022-2836(67)80128-1.
4
Substrate specificity of ribonuclease from Aspergillus saitoi.斋藤曲霉核糖核酸酶的底物特异性
J Biochem. 1968 Nov;64(5):595-602. doi: 10.1093/oxfordjournals.jbchem.a128936.
5
Comparative studies on homopolymers of adenylic acid possessing different C-2' substituents of the furanose. Poly(deoxyriboadenylic acid), poly(riboadenylic acid),poly(2'-O-methyladenylic acid), and poly(2'-O-ethyladenylic acid).对呋喃糖具有不同C-2'取代基的腺苷酸均聚物的比较研究。聚（脱氧核糖腺苷酸）、聚（核糖腺苷酸）、聚（2'-O-甲基腺苷酸）和聚（2'-O-乙基腺苷酸）。
Biochemistry. 1974 Apr 9;13(8):1615-22. doi: 10.1021/bi00705a010.
6
Polynucleotides. XLV Synthesis and properties of poly(2'-azido-2'-deoxyinosinic acid).多核苷酸。XLV. 聚（2'-叠氮基-2'-脱氧肌苷酸）的合成与性质
Nucleic Acids Res. 1977 Aug;4(8):2629-39. doi: 10.1093/nar/4.8.2629.
7
Polynucleotides. XLVI. 1 Synthesis and properties of poly (2'-amino-2'-deoxyadenylic acid).多核苷酸。XLVI。1. 聚（2'-氨基-2'-脱氧腺苷酸）的合成与性质
Nucleic Acids Res. 1977 Apr;4(4):989-1000. doi: 10.1093/nar/4.4.989.
8
Polynucleotides. XL. Synthesis and properties of poly 2'-azido-2'-deoxyadenylic acid.多核苷酸。XL。聚2'-叠氮基-2'-脱氧腺苷酸的合成及性质
Nucleic Acids Res. 1976 Aug;3(8):2089-99. doi: 10.1093/nar/3.8.2089.

多核苷酸。L.聚（2'-氯-2'-脱氧腺苷酸）和聚（2'-溴-2'-脱氧腺苷酸）的合成及性质

Polynucleotides. L. Synthesis and properties of poly (2'-chloro-2'-deoxyadenylic acid) and poly (2'-bromo-2'-deoxyadenylic acid).

作者信息

Ikehara M, Fukui T, Kakiuchi N

出版信息

Nucleic Acids Res. 1977 Dec;4(12):4249-60. doi: 10.1093/nar/4.12.4249.

DOI:10.1093/nar/4.12.4249
PMID:341084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC343238/
Abstract

Poly (2'-chloro-2'-deoxyadenylic acid) and poly (2'-bromo-2'-deoxyadenylic acid) were synthesized from the corresponding diphosphates with the aid of polynucleotide phosphorylase from E. coli. UV, CD, acid titration and mixing with poly (U) were investigated. Comparing these properties with those of poly (A) and poly (2'-azido-2'-deoxyadenylic acid), it was found that 2''substituents exert significant effects on the thermal stability of these polynucleotides, though the overall conformational structure was not greatly changed.

摘要

聚（2'-氯-2'-脱氧腺苷酸）和聚（2'-溴-2'-脱氧腺苷酸）由相应的二磷酸酯借助大肠杆菌的多核苷酸磷酸化酶合成。对其进行了紫外、圆二色、酸滴定以及与聚（U）混合等研究。将这些性质与聚（A）和聚（2'-叠氮基-2'-脱氧腺苷酸）的性质进行比较后发现，尽管整体构象结构变化不大，但2''取代基对这些多核苷酸的热稳定性有显著影响。