Department of Psychobiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil *Contributed equally.
J Clin Sleep Med. 2021 Dec 1;17(12):2439-2449. doi: 10.5664/jcsm.9452.
Obstructive sleep apnea and short sleep duration have been separately associated with inadequate serum 25-hydroxyvitamin D [25(OH)D] levels. However, whether these 2 factors may concurrently influence 25(OH)D in the general population is unknown. We hypothesized that both obstructive sleep apnea and short sleep duration would be independently associated with lower concentrations of 25(OH)D in a sex-dependent manner.
In this cross-sectional study, 712 individuals, part of the prospective EPISONO cohort (Brazil), underwent polysomnography, answered sleep questionnaires, and had their blood collected for serum 25(OH)D quantification.
Individuals with a sleep duration of < 6 hours had 2-fold increased odds of 25(OH)D < 20 ng/mL compared with those who reported 6 or more hours of sleep, even after adjusting for confounding factors. Subset sex analysis revealed that men with a sleep duration of < 6 hours had 4-fold increased odds of 25(OH)D < 20 ng/mL. In women, short sleep duration was not associated with lower 25(OH)D levels. The presence of obstructive sleep apnea (as classified according to the individual's apnea-hypopnea index) was not independently related to 25(OH)D concentrations in men or women. Sleep parameters, including sleep latency and sleep efficiency, had no association with 25(OH)D < 20 ng/mL.
Short sleep, but not apnea-hypopnea index, was an independent factor associated with low 25(OH)D serum levels in men, but not in women. Apnea-hypopnea index scores were not associated with 25(OH)D levels in either sex. These results raise the possibility of investigating sex-specific characteristics, such as gonadal hormone regulation, and re-evaluating obstructive events by classifying them in mild, moderate, and severe obstructive sleep apnea.
de Oliveira DL, Dokkedal-Silva V, Fernandes GL, Kim LJ, Tufik S, Andersen ML. Sleep duration as an independent factor associated with vitamin D levels in the EPISONO cohort. . 2021;17(12):2439-2449.
阻塞性睡眠呼吸暂停和睡眠时间短均与血清 25-羟维生素 D[25(OH)D]水平不足有关。然而，这两个因素是否可能同时影响一般人群中的 25(OH)D 尚不清楚。我们假设阻塞性睡眠呼吸暂停和睡眠时间短都会以性别依赖的方式独立与较低的 25(OH)D 浓度相关。
在这项横断面研究中，巴西前瞻性 EPISONO 队列的 712 名个体接受了多导睡眠图检查，回答了睡眠问卷，并采集了血液样本以检测血清 25(OH)D 浓度。
与睡眠时间超过 6 小时的个体相比，睡眠时间少于 6 小时的个体 25(OH)D<20ng/ml 的可能性增加了两倍，即使在调整了混杂因素后也是如此。亚组性别分析显示，睡眠时间少于 6 小时的男性 25(OH)D<20ng/ml 的可能性增加了四倍。在女性中，睡眠时间短与较低的 25(OH)D 水平无关。阻塞性睡眠呼吸暂停的存在（根据个体的呼吸暂停低通气指数进行分类）与男性或女性的 25(OH)D 浓度没有独立关系。睡眠参数，包括睡眠潜伏期和睡眠效率，与 25(OH)D<20ng/ml 无关。
短时间睡眠，而不是呼吸暂停低通气指数，是男性 25(OH)D 血清水平低的独立因素，但女性则不然。呼吸暂停低通气指数与两性的 25(OH)D 水平均无关联。这些结果提示有可能研究性别特异性特征，如性腺激素调节，并通过将阻塞性事件分类为轻度、中度和重度阻塞性睡眠呼吸暂停来重新评估。
de Oliveira DL, Dokkedal-Silva V, Fernandes GL, Kim LJ, Tufik S, Andersen ML. 睡眠时长作为 EPISONO 队列维生素 D 水平的独立影响因素。 。2021;17(12):2439-2449.
