Li Jingang, Chen Zhihan, Liu Yaoran, Kollipara Pavana Siddhartha, Feng Yichao, Zhang Zhenglong, Zheng Yuebing
Materials Science and Engineering Program and Texas Materials Institute, The University of Texas at Austin, Austin, TX 78712, USA.
Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX 78705, USA.
Sci Adv. 2021 Jun 25;7(26). doi: 10.1126/sciadv.abh1101. Print 2021 Jun.
Optical tweezers offer revolutionary opportunities for both fundamental and applied research in materials science, biology, and medical engineering. However, the requirement of a strongly focused and high-intensity laser beam results in potential photon-induced and thermal damages to target objects, including nanoparticles, cells, and biomolecules. Here, we report a new type of light-based tweezers, termed opto-refrigerative tweezers, which exploit solid-state optical refrigeration and thermophoresis to trap particles and molecules at the laser-generated cold region. While laser refrigeration can avoid photothermal heating, the use of a weakly focused laser beam can further reduce the photodamages to the target object. This novel and noninvasive optical tweezing technique will bring new possibilities in the optical control of nanomaterials and biomolecules for essential applications in nanotechnology, photonics, and life science.
光镊为材料科学、生物学和医学工程等领域的基础研究和应用研究提供了革命性的机遇。然而，由于需要强聚焦和高强度的激光束，这可能会对包括纳米颗粒、细胞和生物分子在内的目标物体造成潜在的光子诱导损伤和热损伤。在此，我们报告了一种新型的基于光的镊子，称为光致冷镊子，它利用固态光制冷和热泳现象在激光产生的冷区捕获粒子和分子。虽然激光制冷可以避免光热加热，但使用弱聚焦激光束可以进一步减少对目标物体的光损伤。这种新颖的非侵入式光镊技术将为纳米材料和生物分子的光学控制带来新的可能性，从而在纳米技术、光子学和生命科学等重要应用中发挥作用。
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