• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Role of endothelial cells in tumor microenvironment.

作者信息

Yang Dawei, Guo Peipei, He Tianrui, Powell Charles A

机构信息

Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital Institute for Clinical Science, Shanghai Medical College, Shanghai Engineering Research Center of AI Technology for Cardiopulmonary Diseases, Shanghai Engineer & Technology Research Center of Internet of Things for Respiratory Medicine, Zhongshan Hospital Fudan University, Shanghai, 200032, China.

Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

出版信息

Clin Transl Med. 2021 Jun;11(6):e450. doi: 10.1002/ctm2.450.

DOI:10.1002/ctm2.450
PMID:34185401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8214858/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13db/8214858/c1a9de5f66a7/CTM2-11-e450-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13db/8214858/06f37af8a130/CTM2-11-e450-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13db/8214858/c1a9de5f66a7/CTM2-11-e450-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13db/8214858/06f37af8a130/CTM2-11-e450-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13db/8214858/c1a9de5f66a7/CTM2-11-e450-g002.jpg

相似文献

1
Role of endothelial cells in tumor microenvironment.内皮细胞在肿瘤微环境中的作用。
Clin Transl Med. 2021 Jun;11(6):e450. doi: 10.1002/ctm2.450.
2
Tumor microenvironment: a mechanical force link.肿瘤微环境：一种机械力联系。
Sci China Life Sci. 2015 Feb;58(2):202-4. doi: 10.1007/s11427-014-4796-x. Epub 2015 Jan 6.
3
Altered angiogenesis in the tumor microenvironment.肿瘤微环境中的血管生成改变。
Pathol Int. 2011 Nov;61(11):630-7. doi: 10.1111/j.1440-1827.2011.02726.x. Epub 2011 Oct 10.
4
Endothelial cell autophagy in homeostasis and cancer.内皮细胞自噬在稳态和癌症中的作用。
FEBS Lett. 2021 Jun;595(11):1497-1511. doi: 10.1002/1873-3468.14087. Epub 2021 Apr 24.
5
Microvascular Mural Cells in Cancer.癌症中的微血管壁细胞
Trends Cancer. 2018 Dec;4(12):838-848. doi: 10.1016/j.trecan.2018.10.004. Epub 2018 Oct 28.
6
B cells and cancer: To B or not to B?B 细胞与癌症：B 细胞要不要？
J Exp Med. 2021 Jan 4;218(1). doi: 10.1084/jem.20200851.
7
Tumor endothelial cells accelerate tumor metastasis.肿瘤内皮细胞加速肿瘤转移。
Cancer Sci. 2017 Oct;108(10):1921-1926. doi: 10.1111/cas.13336. Epub 2017 Aug 17.
8
Pathological angiogenesis and inflammation in tissues.组织中的病理性血管生成和炎症。
Arch Pharm Res. 2021 Jan;44(1):1-15. doi: 10.1007/s12272-020-01287-2. Epub 2020 Nov 23.
9
Optimizing Chemotherapeutic Anti-cancer Treatment and the Tumor Microenvironment: An Analysis of Mathematical Models.优化化疗抗癌治疗与肿瘤微环境：数学模型分析
Adv Exp Med Biol. 2016;936:209-223. doi: 10.1007/978-3-319-42023-3_11.
10
The crossroad between tumor and endothelial cells.肿瘤细胞与内皮细胞的交叉路口。
Clin Exp Med. 2024 Sep 26;24(1):227. doi: 10.1007/s10238-024-01490-1.

引用本文的文献

1
Mechanisms of Cancer Cell Lymphatic Endothelialization in Tumor Lymphangiogenesis and Metastasis: A Comprehensive Review.肿瘤淋巴管生成和转移中癌细胞淋巴管内皮化的机制：综述
J Inflamm Res. 2025 Aug 9;18:10741-10750. doi: 10.2147/JIR.S535351. eCollection 2025.
2
Immune organoid for cancer immunotherapy.用于癌症免疫治疗的免疫类器官
Acta Pharm Sin B. 2025 Jul;15(7):3419-3435. doi: 10.1016/j.apsb.2025.04.031. Epub 2025 May 17.
3
Promoting Immune Response of Human Vascular Endothelial Cells by Bevacizumab: Insights into the Immune Supportive Role of Anti-VEGF Therapy.

本文引用的文献

1
Capillary cell-type specialization in the alveolus.肺泡毛细血管细胞类型特化。
Nature. 2020 Oct;586(7831):785-789. doi: 10.1038/s41586-020-2822-7. Epub 2020 Oct 14.
2
A refocus on the advances of single-cell biomedicine.重新聚焦单细胞生物医学的进展。
Cell Biol Toxicol. 2020 Oct;36(5):395-398. doi: 10.1007/s10565-020-09551-3. Epub 2020 Aug 10.
3
Extracellular vesicles from genetically unstable, oncogene-driven cancer cells trigger micronuclei formation in endothelial cells.遗传不稳定、致癌基因驱动的癌细胞释放的细胞外囊泡可引发内皮细胞微核形成。
贝伐单抗对人血管内皮细胞免疫反应的促进作用：抗VEGF治疗免疫支持作用的见解
Int J Mol Sci. 2025 Jun 29;26(13):6280. doi: 10.3390/ijms26136280.
4
TMBIM6 promotes glioma progression according to integrated bioinformatics and experimental evidence.根据综合生物信息学和实验证据，TMBIM6促进胶质瘤进展。
Sci Rep. 2025 Jul 1;15(1):21422. doi: 10.1038/s41598-025-06799-9.
5
Gut Microbiota Reshapes the Tumor Microenvironment and Affects the Efficacy of Colorectal Cancer Immunotherapy.肠道微生物群重塑肿瘤微环境并影响结直肠癌免疫治疗的疗效。
Cancer Med. 2025 Jun;14(12):e70994. doi: 10.1002/cam4.70994.
6
Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy.针对具有细胞类型特异性功能的细胞内蛋白质进行癌症免疫治疗。
Life Med. 2023 Jun 17;2(3):lnad019. doi: 10.1093/lifemedi/lnad019. eCollection 2023 Jun.
7
Targeting Cancer: Microenvironment and Immunotherapy Innovations.靶向癌症：微环境与免疫治疗创新
Int J Mol Sci. 2024 Dec 18;25(24):13569. doi: 10.3390/ijms252413569.
8
Exploring the Complexity of Pan-Cancer: Gene Convergences and in silico Analyses.探索泛癌的复杂性：基因汇聚与计算机模拟分析。
Breast Cancer (Dove Med Press). 2024 Dec 13;16:913-934. doi: 10.2147/BCTT.S489246. eCollection 2024.
9
aKNNO: single-cell and spatial transcriptomics clustering with an optimized adaptive k-nearest neighbor graph.aKNNO：使用优化的自适应k近邻图进行单细胞和空间转录组学聚类
Genome Biol. 2024 Aug 1;25(1):203. doi: 10.1186/s13059-024-03339-y.
10
Single-cell signatures identify microenvironment factors in tumors associated with patient outcomes.单细胞特征可识别与患者预后相关的肿瘤微环境因素。
Cell Rep Methods. 2024 Jun 17;4(6):100799. doi: 10.1016/j.crmeth.2024.100799.
Sci Rep. 2020 May 22;10(1):8532. doi: 10.1038/s41598-020-65640-7.
4
A novel proangiogenic B cell subset is increased in cancer and chronic inflammation.一种新型的促血管生成 B 细胞亚群在癌症和慢性炎症中增加。
Sci Adv. 2020 May 13;6(20):eaaz3559. doi: 10.1126/sciadv.aaz3559. eCollection 2020 May.
5
A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors.单细胞和单细胞核 RNA-Seq 工具包，适用于新鲜和冷冻的人类肿瘤。
Nat Med. 2020 May;26(5):792-802. doi: 10.1038/s41591-020-0844-1. Epub 2020 May 11.
6
SOX4 activates CXCL12 in hepatocellular carcinoma cells to modulate endothelial cell migration and angiogenesis in vivo.SOX4 在肝癌细胞中激活 CXCL12，从而调节体内内皮细胞的迁移和血管生成。
Oncogene. 2020 Jun;39(24):4695-4710. doi: 10.1038/s41388-020-1319-z. Epub 2020 May 13.
7
Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma.阿替利珠单抗联合贝伐珠单抗治疗不可切除肝细胞癌。
N Engl J Med. 2020 May 14;382(20):1894-1905. doi: 10.1056/NEJMoa1915745.
8
Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma.单细胞 RNA 测序显示转移性肺腺癌的分子和细胞重编程。
Nat Commun. 2020 May 8;11(1):2285. doi: 10.1038/s41467-020-16164-1.
9
Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors.利用基于 Apelin 的合成 Notch 受体来检测血管生成和治疗实体瘤。
Nat Commun. 2020 May 1;11(1):2163. doi: 10.1038/s41467-020-15729-4.
10
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.单细胞分析为结直肠癌中针对髓系细胞的治疗机制提供信息。
Cell. 2020 Apr 16;181(2):442-459.e29. doi: 10.1016/j.cell.2020.03.048.