Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning Province 110016, PR China.
Wuya College of innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning Province 110016, PR China.
J Control Release. 2023 Nov;363:180-200. doi: 10.1016/j.jconrel.2023.09.035. Epub 2023 Sep 27.
Wound healing is a crucial process that restores the integrity and function of the skin and other tissues after injury. However, external factors, such as infection and inflammation, can impair wound healing and cause severe tissue damage. Therefore, developing new drugs or methods to promote wound healing is of great significance. Photothermal therapy (PTT) is a promising technique that uses photothermal agents (PTAs) to convert near-infrared radiation into heat, which can eliminate bacteria and stimulate tissue regeneration. PTT has the advantages of high efficiency, controllability, and low drug resistance. Hence, nanomaterial-based PTT and its related strategies have been widely explored for wound healing applications. However, a comprehensive review of PTT-related strategies for wound healing is still lacking. In this review, we introduce the physiological mechanisms and influencing factors of wound healing, and summarize the types of PTAs commonly used for wound healing. Then, we discuss the strategies for designing nanocomposites for multimodal combination treatment of wounds. Moreover, we review methods to improve the therapeutic efficacy of PTT for wound healing, such as selecting the appropriate wound dressing form, controlling drug release, and changing the infrared irradiation window. Finally, we address the challenges of PTT in wound healing and suggest future directions.
伤口愈合是一个关键过程，它可以在受伤后恢复皮肤和其他组织的完整性和功能。然而，外部因素，如感染和炎症，会损害伤口愈合并导致严重的组织损伤。因此，开发新的药物或方法来促进伤口愈合具有重要意义。光热疗法（PTT）是一种很有前途的技术，它使用光热剂（PTAs）将近红外辐射转化为热量，从而可以消除细菌并刺激组织再生。PTT 具有高效、可控和低耐药性的优点。因此，基于纳米材料的 PTT 及其相关策略已被广泛探索用于伤口愈合应用。然而，对于 PTT 相关策略用于伤口愈合的综合综述仍然缺乏。在这篇综述中，我们介绍了伤口愈合的生理机制和影响因素，并总结了常用于伤口愈合的 PTA 类型。然后，我们讨论了设计用于多模式联合治疗伤口的纳米复合材料的策略。此外，我们还回顾了提高 PTT 治疗伤口愈合疗效的方法，例如选择合适的伤口敷料形式、控制药物释放和改变红外辐射窗口。最后，我们讨论了 PTT 在伤口愈合中的挑战，并提出了未来的方向。
