• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

卵巢反应不良女性在4个完整周期后累积活产率并未增加：一项对1825例患者的回顾性研究。

Cumulative live birth rates do not increase after 4 complete cycles in women with poor ovarian response: a retrospective study of 1,825 patients.

作者信息

Wang Meng, Jia Lei, Li Xiao-Lan, Guo Jia-Yi, Fang Cong, Huang Rui, Liang Xiao-Yan

机构信息

Reproductive Medicine Center, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

出版信息

F S Rep. 2021 Feb 2;2(2):201-208. doi: 10.1016/j.xfre.2021.01.004. eCollection 2021 Jun.

DOI:10.1016/j.xfre.2021.01.004
PMID:34278355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8267389/
Abstract

OBJECTIVE

To investigate whether the cumulative clinical pregnancy rates (CCPR) and cumulative live birth rates (CLBR) increase as the oocyte retrieval cycle increases in women with poor ovarian response.

DESIGN

Retrospective cohort study.

SETTING

Not applicable.

PATIENTS

Women diagnosed of poor ovarian response (POR) according to the Bologna criteria and who completed in vitro fertilization or intracytoplasmic sperm injection cycles between January 2014 and December 2018.

INTERVENTIONS

Not applicable.

MAIN OUTCOME MEASURES

The conservative and optimistic estimations of CCPR and CLBR.

RESULTS

The conservative and optimistic estimates of CCPR peaked at the 6th complete cycle, reaching 36.44% and 71.61%, respectively. However, the conservative and optimistic estimates of CLBR peaked at the 4th complete cycle, reaching 20.22% and 38.31%, respectively. The live birth rate per complete cycle of mild stimulation protocol was comparable to other protocols after adjusting for the confounding factors. For patients ≤35 years, the live birth rate per complete cycle of progestin-primed ovarian stimulation (adjusted odds ratio = 0.51, 95% confidence interval: 0.30-0.87) and gonadotropin-releasing hormone antagonist protocol (adjusted odds ratio=0.45, 95% confidence interval: 0.24-0.81) were significantly lower than that of the mild stimulation.

CONCLUSIONS

It is not advisable to initiate more than four complete cycles for POR patients since CLBR do not increase after that. For POR patients ≤35 years, the live birth rate per complete cycle increased in women with mild stimulation protocol.

摘要

目的

探讨卵巢反应不良女性的累积临床妊娠率（CCPR）和累积活产率（CLBR）是否随着取卵周期的增加而升高。

设计

回顾性队列研究。

地点

不适用。

患者

根据博洛尼亚标准诊断为卵巢反应不良（POR）且在2014年1月至2018年12月期间完成体外受精或卵胞浆内单精子注射周期的女性。

干预措施

不适用。

主要观察指标

CCPR和CLBR的保守估计值和乐观估计值。

结果

CCPR的保守估计值和乐观估计值在第6个完整周期达到峰值，分别为36.44%和71.61%。然而，CLBR的保守估计值和乐观估计值在第4个完整周期达到峰值，分别为20.22%和38.31%。在调整混杂因素后，轻度刺激方案每个完整周期的活产率与其他方案相当。对于年龄≤35岁的患者，孕激素预处理卵巢刺激方案（调整后的优势比=0.51，95%置信区间：0.30-0.87）和促性腺激素释放激素拮抗剂方案（调整后的优势比=0.45，95%置信区间：0.24-0.81）每个完整周期的活产率显著低于轻度刺激方案。

结论

对于POR患者，启动超过四个完整周期并不可取，因为此后CLBR不会增加。对于年龄≤35岁的POR患者，轻度刺激方案的每个完整周期活产率有所提高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a500/8267389/e141938080b5/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a500/8267389/2570327afaea/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a500/8267389/e141938080b5/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a500/8267389/2570327afaea/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a500/8267389/e141938080b5/figs1.jpg

相似文献

1
Cumulative live birth rates do not increase after 4 complete cycles in women with poor ovarian response: a retrospective study of 1,825 patients.卵巢反应不良女性在4个完整周期后累积活产率并未增加：一项对1825例患者的回顾性研究。
F S Rep. 2021 Feb 2;2(2):201-208. doi: 10.1016/j.xfre.2021.01.004. eCollection 2021 Jun.
2
Progestin-Primed Ovarian Stimulation Versus Mild Stimulation Protocol in Advanced Age Women With Diminished Ovarian Reserve Undergoing Their First Fertilization Cycle: A Retrospective Cohort Study.孕激素预处理卵巢刺激与轻度刺激方案在卵巢储备功能减退高龄患者行首次体外受精周期中的应用：一项回顾性队列研究。
Front Endocrinol (Lausanne). 2022 Jan 24;12:801026. doi: 10.3389/fendo.2021.801026. eCollection 2021.
3
Cumulative live birth rates in more than 3,000 patients with poor ovarian response: a 15-year survey of final in vitro fertilization outcome.3000 余例卵巢低反应患者的累计活产率：15 年体外受精结局调查。
Fertil Steril. 2018 Jun;109(6):1051-1059. doi: 10.1016/j.fertnstert.2018.02.001.
4
The number of oocytes associated with maximum cumulative live birth rates per aspiration depends on female age: a population study of 221 221 treatment cycles.与每个抽吸相关的最大累积活产率相关的卵母细胞数量取决于女性年龄：221221 个治疗周期的人群研究。
Hum Reprod. 2019 Sep 29;34(9):1778-1787. doi: 10.1093/humrep/dez100.
5
Cumulative Live Birth Rate and Cost-Effectiveness Analysis of Gonadotropin Releasing Hormone-Antagonist Protocol and Multiple Minimal Ovarian Stimulation in Poor Responders.促性腺激素释放激素拮抗剂方案与多次微刺激对卵巢低反应患者的累积活产率和成本效益分析。
Front Endocrinol (Lausanne). 2021 Jan 14;11:605939. doi: 10.3389/fendo.2020.605939. eCollection 2020.
6
[Cumulative live birth rates per oocytes retrieved cycle: evaluation of clinical outcomes of IVF/ICSI].[每个取卵周期的累积活产率：体外受精/卵胞浆内单精子注射临床结局评估]
Zhonghua Fu Chan Ke Za Zhi. 2018 Mar 25;53(3):160-166. doi: 10.3760/cma.j.issn.0529-567X.2018.03.004.
7
Cumulative live birth rates in low-prognosis women.低预后女性的累积活产率。
Hum Reprod. 2019 Jun 4;34(6):1030-1041. doi: 10.1093/humrep/dez051.
8
Cumulative live birth rates after one ART cycle including all subsequent frozen-thaw cycles in 1050 women: secondary outcome of an RCT comparing GnRH-antagonist and GnRH-agonist protocols.1050名女性在一个辅助生殖技术周期（包括所有后续冻融周期）后的累积活产率：一项比较促性腺激素释放激素拮抗剂和促性腺激素释放激素激动剂方案的随机对照试验的次要结果。
Hum Reprod. 2017 Mar 1;32(3):556-567. doi: 10.1093/humrep/dew358.
9
Comparison of the Cumulative Live Birth Rates of Progestin-Primed Ovarian Stimulation and Flexible GnRH Antagonist Protocols in Patients With Low Prognosis.孕激素预处理卵巢刺激与灵活 GnRH 拮抗剂方案在低预后患者中累积活产率的比较。
Front Endocrinol (Lausanne). 2021 Sep 13;12:705264. doi: 10.3389/fendo.2021.705264. eCollection 2021.
10
Dual Trigger for Final Follicular Maturation Improves Cumulative Live-Birth Rate in Ovarian Stimulation for Freeze-All Fertilization/Intracytoplasmic Sperm Injection Cycles.双重触发对冻融胚胎移植周期中卵子刺激的最终卵泡成熟有改善作用，可提高累积活产率。
Front Endocrinol (Lausanne). 2021 Jul 19;12:708247. doi: 10.3389/fendo.2021.708247. eCollection 2021.

引用本文的文献

1
Intra-ovarian platelet-rich plasma administration plus successive accumulated embryo transfer could be a promising strategy for poor ovarian response management: a before-after study.卵巢内注射富含血小板血浆加连续累积胚胎移植可能是一种治疗卵巢反应不良的有前景的策略：一项前后对照研究。
J Ovarian Res. 2025 Mar 28;18(1):64. doi: 10.1186/s13048-025-01646-x.
2
Progestin-Primed Ovarian Stimulation Versus Mild Stimulation Protocol in Advanced Age Women With Diminished Ovarian Reserve Undergoing Their First Fertilization Cycle: A Retrospective Cohort Study.孕激素预处理卵巢刺激与轻度刺激方案在卵巢储备功能减退高龄患者行首次体外受精周期中的应用：一项回顾性队列研究。
Front Endocrinol (Lausanne). 2022 Jan 24;12:801026. doi: 10.3389/fendo.2021.801026. eCollection 2021.

本文引用的文献

1
The number of oocytes associated with maximum cumulative live birth rates per aspiration depends on female age: a population study of 221 221 treatment cycles.与每个抽吸相关的最大累积活产率相关的卵母细胞数量取决于女性年龄：221221 个治疗周期的人群研究。
Hum Reprod. 2019 Sep 29;34(9):1778-1787. doi: 10.1093/humrep/dez100.
2
Effect of exogenous gonadotropin on the transcriptome of human granulosa cells and follicular fluid hormone profiles.外源促性腺激素对人颗粒细胞转录组和卵泡液激素谱的影响。
Reprod Biol Endocrinol. 2019 Jun 24;17(1):49. doi: 10.1186/s12958-019-0489-4.
3
Cumulative live birth rates in low-prognosis women.
低预后女性的累积活产率。
Hum Reprod. 2019 Jun 4;34(6):1030-1041. doi: 10.1093/humrep/dez051.
4
Apoptosis of mural granulosa cells is increased in women with diminished ovarian reserve.卵巢储备功能降低的女性，壁层颗粒细胞凋亡增加。
J Assist Reprod Genet. 2019 Jun;36(6):1225-1235. doi: 10.1007/s10815-019-01446-5. Epub 2019 Apr 13.
5
Cumulative live birth rate of advanced-age women more than 40 with or without poor ovarian response.40岁及以上卵巢反应正常或不良的高龄女性的累积活产率
Taiwan J Obstet Gynecol. 2019 Mar;58(2):201-205. doi: 10.1016/j.tjog.2019.01.006.
6
Ovarian ageing and the impact on female fertility.卵巢衰老及其对女性生育能力的影响。
F1000Res. 2018 Nov 22;7. doi: 10.12688/f1000research.16509.1. eCollection 2018.
7
Establishment of an improved vitrification protocol by combinations of vitrification medium for isolated mouse ovarian follicles.通过组合用于分离小鼠卵巢卵泡的玻璃化介质建立改进的玻璃化方案。
Theriogenology. 2018 Nov;121:97-103. doi: 10.1016/j.theriogenology.2018.07.022. Epub 2018 Aug 3.
8
Comparison of pregnancy rates for poor responders using IVF with mild ovarian stimulation versus conventional IVF: a guideline.使用轻度卵巢刺激的体外受精与常规体外受精治疗卵巢低反应患者的妊娠率比较：指南。
Fertil Steril. 2018 Jun;109(6):993-999. doi: 10.1016/j.fertnstert.2018.03.019.
9
Cumulative live birth rates in more than 3,000 patients with poor ovarian response: a 15-year survey of final in vitro fertilization outcome.3000 余例卵巢低反应患者的累计活产率：15 年体外受精结局调查。
Fertil Steril. 2018 Jun;109(6):1051-1059. doi: 10.1016/j.fertnstert.2018.02.001.
10
Should all embryos be cultured to blastocyst for advanced maternal age women with low ovarian reserve: a single center retrospective study.对于卵巢储备功能低下的高龄产妇，所有胚胎都应培养至囊胚阶段吗：一项单中心回顾性研究
Gynecol Endocrinol. 2018 Sep;34(9):761-765. doi: 10.1080/09513590.2018.1450379. Epub 2018 Mar 16.