Hamdi Hamida, Hassan Montaser M
Department of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Saudi J Biol Sci. 2021 Aug;28(8):4778-4785. doi: 10.1016/j.sjbs.2021.05.003. Epub 2021 May 8.
Although Nanoalumina is widely used in many biomedical applications, its potential toxic effect on pregnant women and developing embryos/fetuses has not been reported. In this investigation, the maternal and developmental toxicity caused by Nanoalumina during gestation and the potential preventive role of the pumpkin seed oil (PSO) were evaluated. Four groups of pregnant rats were orally administered during days 5-19 of gestation as follows: control group, Nanoalumina group (70 mg/kg b.w), PSO- group (4 ml/kg b.w.), and Nanoalumina plus PSO- group. Nanoalumina induced detrimental impacts in pregnancy outcomes, fetal growth retardation, morphological anomalies, hepatic and neural DNA damage, and histopathological changes in hepatic and neural tissues of both mother and fetus, respectively. Furthermore, the level of MDA is significantly increased and activities of GSH and CAT are significantly reduced in both tissues of nanoalumina-administered rats. PSO co administration improved pregnancy outcomes, fetal growth parameters, DNA damage, antioxidant defenses the histopathological changes of nanoalumina-gavaged rats and significantly diminished MDA level. Finally, PSO has a preventive role against the detrimental impacts of nanoalumina in dams and fetuses probably via its potential to prevent reactive oxygen species.
尽管纳米氧化铝在许多生物医学应用中被广泛使用，但其对孕妇和发育中的胚胎/胎儿的潜在毒性作用尚未见报道。在本研究中，评估了纳米氧化铝在妊娠期引起的母体和发育毒性以及南瓜籽油（PSO）的潜在预防作用。将四组怀孕大鼠在妊娠第5至19天经口给药，具体如下：对照组、纳米氧化铝组（70毫克/千克体重）、PSO组（4毫升/千克体重）和纳米氧化铝加PSO组。纳米氧化铝分别对妊娠结局、胎儿生长迟缓、形态异常、肝脏和神经DNA损伤以及母体和胎儿的肝脏和神经组织的组织病理学变化产生有害影响。此外，给予纳米氧化铝的大鼠的两种组织中丙二醛水平显著升高，谷胱甘肽和过氧化氢酶活性显著降低。PSO共同给药改善了纳米氧化铝灌胃大鼠的妊娠结局、胎儿生长参数、DNA损伤、抗氧化防御和组织病理学变化，并显著降低了丙二醛水平。最后，PSO可能通过其预防活性氧的潜力，对纳米氧化铝对母鼠和胎儿的有害影响具有预防作用。
