Underwood J C, Giri D D, Rooney N, Lonsdale R
Department of Pathology, University of Sheffield Medical School, UK.
Br J Cancer. 1987 Dec;56(6):744-6. doi: 10.1038/bjc.1987.281.
Several studies of breast tumour histology and oestrogen receptor (ER) contents report an inverse correlation between the density of the stromal lymphoid cell infiltrate and the presence or concentration of ER. Using monoclonal antibodies to lymphoid cell surface markers we have examined the immunophenotype of the infiltrating lymphoid cells and related this to the tumour ER content. There is a significant inverse correlation between the presence of Leu7-positive cells, which includes a subpopulation of natural killer (NK) cells, and tumour ER content; this is possibly superimposed on the dilutional effect of macrophages and other infiltrating cells.
多项关于乳腺肿瘤组织学和雌激素受体（ER）含量的研究报告称，基质淋巴样细胞浸润密度与ER的存在或浓度之间呈负相关。我们使用针对淋巴样细胞表面标志物的单克隆抗体，检测了浸润性淋巴样细胞的免疫表型，并将其与肿瘤ER含量相关联。包括自然杀伤（NK）细胞亚群在内的Leu7阳性细胞的存在与肿瘤ER含量之间存在显著负相关；这可能叠加在巨噬细胞和其他浸润细胞的稀释作用之上。
