氨苄西林和氯霉素对肺炎链球菌和脑膜炎奈瑟菌的作用。
Effect of ampicillin and chloramphenicol against Streptococcus pneumoniae and Neisseria meningitidis.
作者信息
Feldman W E, Zweighaft T
出版信息
Antimicrob Agents Chemother. 1979 Feb;15(2):240-42. doi: 10.1128/AAC.15.2.240.
Abstract
Antagonism, determined by isobolograms constructed from data from combinations of ampicillin and chloramphenicol at or below the minimal inhibitory or bactericidal concentrations, was observed against 13 clinical isolates of meningococcus and against one isolate of pneumococcus. Synergy occurred against six strains of pneumococcus and three of meningococcus. Additive effects were noted against 14 isolates of pneumococcus and 5 of meningococcus. There was no relationship between the minimal inhibitory or bactericidal concentrations for the isolates and the occurrence of antagonistic, additive, or synergistic effects. These data indicate that ampicillin and chloramphenicol may be antagonistic in vitro against some strains of pneumococcus or meningococcus.
摘要
通过以低于最小抑菌浓度或杀菌浓度的氨苄西林和氯霉素组合数据构建的等效线图确定，观察到对13株脑膜炎奈瑟菌临床分离株和1株肺炎链球菌分离株有拮抗作用。对6株肺炎链球菌和3株脑膜炎奈瑟菌出现协同作用。对14株肺炎链球菌分离株和5株脑膜炎奈瑟菌观察到相加效应。分离株的最小抑菌浓度或杀菌浓度与拮抗、相加或协同效应的发生之间没有关系。这些数据表明，氨苄西林和氯霉素在体外可能对某些肺炎链球菌或脑膜炎奈瑟菌菌株具有拮抗作用。
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