Gentry Sommer, Chow Eric, Massie Allan, Segev Dorry
Mathematics Department, United States Naval Academy, Annapolis, Maryland 21402; and Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
Interfaces (Providence). 2015 Sep-Oct;45(5):462-480. doi: 10.1287/inte.2015.0810. Epub 2015 Oct 20.
U.S. organ allocation policy sequesters livers from deceased donors within arbitrary geographic boundaries, frustrating the intent of those who wish to offer the livers to transplant candidates based on medical urgency. We used a zero-one integer program to partition 58 donor service areas into between four and eight sharing districts that minimize the disparity in liver availability among districts. Because the integer program necessarily suppressed clinically significant differences among patients and organs, we tested the optimized district maps with a discrete-event simulation tool that represents liver allocation at a per-person, per-organ level of detail. In April 2014, the liver committee of the Organ Procurement and Transplantation Network (OPTN) decided in a unanimous vote of 22-0-0 to write a policy proposal based on our eight-district and four-district maps. The OPTN board of directors could implement the policy after the proposal and public-comment period.Redistricting liver allocation would save hundreds of lives over the next five years and would attenuate the serious geographic inequity in liver transplant offers.
美国的器官分配政策将已故捐赠者的肝脏限定在任意的地理区域内,这让那些希望根据医疗紧急程度将肝脏提供给移植候选人的人感到沮丧。我们使用一个0-1整数规划模型,将58个供体服务区划分为4至8个共享区,以尽量减少各区域间肝脏可获得性的差异。由于整数规划必然会掩盖患者和器官之间临床上的显著差异,我们使用了一个离散事件模拟工具对优化后的分区地图进行测试,该工具能够在逐个患者、逐个器官的详细层面上模拟肝脏分配情况。2014年4月,器官获取与移植网络(OPTN)肝脏委员会以22比0比0的全票表决结果,决定根据我们的八区和四区地图撰写一份政策提案。在提案和公众意见征询期之后,OPTN董事会可以实施该政策。重新划分肝脏分配区域在未来五年内将挽救数百人的生命,并将减轻肝脏移植供体方面严重的地理不平等现象。