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使用脱矿牙移植材料和牛骨进行上颌窦提升术的免疫组织化学分析比较

Comparison of immunohistochemical analysis on sinus augmentation using demineralized tooth graft and bovine bone.

作者信息

Sohn Dong-Seok, Kim Ji-Rak, Kim Hyung-Gyun, Choi Hyun-Suk, Moon Yong-Suk

机构信息

Department of Dentistry and Oral and Maxillofacial Surgery, School of Medicine, Daegu Catholic University, Daegu, Korea.

Department of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu, Korea.

出版信息

J Korean Assoc Oral Maxillofac Surg. 2021 Aug 31;47(4):269-278. doi: 10.5125/jkaoms.2021.47.4.269.

DOI:10.5125/jkaoms.2021.47.4.269
PMID:34462384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8408643/
Abstract

OBJECTIVES

The purpose of this animal research was to compare bone regeneration in augmented rabbit maxillary sinuses treated with demineralized particulate human-tooth graft and anorganic bovine bone by immunohistochemical analysis.

MATERIALS AND METHODS

Piezoelectric bilateral sinus augmentation was performed in eight adult rabbits. In the control group, anorganic bovine was grafted in the maxillary sinus following elevation of the sinus membrane. In the experimental group, demineralized human particulate tooth bone was grafted in the sinus. Bone regeneration in augmented sinuses was evaluated by immunohistochemical analysis using various markers of osteoprogenitor cells.

RESULTS

The number of bromodeoxyuridine-labeled cells was significantly higher in the experimental group than in the control group at eight weeks. The immunoreactivity of proliferating-cell nuclear antigen was increased slightly in the experimental group relative to the control group at eight weeks. Other bone markers were expressed equally in the two groups.

CONCLUSION

In the rabbit maxillary sinus, higher osteoinduction was correlated with demineralized human particulate tooth bone grafting than with anorganic bovine grafting.

摘要

目的

本动物研究的目的是通过免疫组织化学分析比较用脱矿质人牙颗粒移植物和无机牛骨处理的兔上颌窦增强后的骨再生情况。

材料与方法

对8只成年兔进行压电双侧窦增强术。对照组在窦膜抬高后将无机牛骨植入上颌窦。实验组将脱矿质人牙颗粒骨植入窦内。使用各种骨祖细胞标记物通过免疫组织化学分析评估增强窦内的骨再生情况。

结果

在8周时，实验组中溴脱氧尿苷标记的细胞数量显著高于对照组。在8周时，实验组中增殖细胞核抗原的免疫反应性相对于对照组略有增加。其他骨标记物在两组中表达相同。

结论

在兔上颌窦中，与无机牛骨移植相比，脱矿质人牙颗粒骨移植具有更高的骨诱导性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/b9c5758e705f/jkaoms-47-4-269-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/970c33132a3e/jkaoms-47-4-269-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/d5a3494fa5f9/jkaoms-47-4-269-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/8d11688e6d1a/jkaoms-47-4-269-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/c9f2a44e35e5/jkaoms-47-4-269-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/10c7dd11e82c/jkaoms-47-4-269-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/8668bd850bad/jkaoms-47-4-269-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/a87d3e8d37e0/jkaoms-47-4-269-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/b9c5758e705f/jkaoms-47-4-269-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/970c33132a3e/jkaoms-47-4-269-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/d5a3494fa5f9/jkaoms-47-4-269-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/8d11688e6d1a/jkaoms-47-4-269-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/c9f2a44e35e5/jkaoms-47-4-269-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/10c7dd11e82c/jkaoms-47-4-269-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/8668bd850bad/jkaoms-47-4-269-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/a87d3e8d37e0/jkaoms-47-4-269-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5670/8408643/b9c5758e705f/jkaoms-47-4-269-f8.jpg

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