Kardeh Sina, Moein Seyed Arman, Namazi Mohammad Reza, Kardeh Bahareh
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Cellular and Molecular Medicine Student Research Group, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Galen Med J. 2019 Apr 10;8:e1291. doi: 10.31661/gmj.v0i0.1291. eCollection 2019.
Acne vulgaris is a common inflammatory skin disorder which is recognizable by dermatological lesions and scars. In addition to some pathogenetic factors such as hyperkeratinization, upregulated sebum secretion, and immunoinflammatory reactions, recent studies have also connected oxidative stress to the pathogenesis of acne vulgaris. In this article, we will briefly review clinical studies that interrogated alterations in oxidative stress biomarkers by a systematic search conducted in PubMed, Web of Science, and Scopus using "acne", "oxidative stress", and "reactive oxygen species" keywords. Overall, studies have shown that oxidative biomarkers (e.g. lipid peroxidation final products) are higher in acne vulgaris lesions. A significant positive correlation has also been noted between acne severity and oxidative biomarkers. In contrast, diminished levels of antioxidant enzymes (e.g. superoxide dismutase and catalase) have been observed in acne. We propose four probable mechanisms for the role of reactive oxygen species (ROS) in acne pathogenesis. We believe that ROS can contribute significantly to the acne vulgaris pathobiology via toll-like receptor (TLR), peroxisome proliferator-activated receptor (PPAR), mTOR pathway, and innate immune system, resulting in inflammation by alterations in the generation of several proinflammatory cytokines including IL-1, IL-8, and TNF-α.
寻常痤疮是一种常见的炎症性皮肤病，可通过皮肤病变和疤痕识别。除了一些致病因素，如过度角化、皮脂分泌上调和免疫炎症反应外，最近的研究还将氧化应激与寻常痤疮的发病机制联系起来。在本文中，我们将简要回顾通过在PubMed、科学网和Scopus中使用“痤疮”、“氧化应激”和“活性氧”关键词进行系统检索来探究氧化应激生物标志物变化的临床研究。总体而言，研究表明氧化生物标志物（如脂质过氧化终产物）在寻常痤疮病变中较高。痤疮严重程度与氧化生物标志物之间也存在显著正相关。相比之下，在痤疮中观察到抗氧化酶（如超氧化物歧化酶和过氧化氢酶）水平降低。我们提出了活性氧（ROS）在痤疮发病机制中作用的四种可能机制。我们认为ROS可通过Toll样受体（TLR）、过氧化物酶体增殖物激活受体（PPAR）、mTOR途径和先天免疫系统对寻常痤疮病理生物学产生重大影响，通过改变包括IL-1、IL-8和TNF-α在内的几种促炎细胞因子的产生导致炎症。
