Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu, China.
Front Endocrinol (Lausanne). 2021 Aug 17;12:667951. doi: 10.3389/fendo.2021.667951. eCollection 2021.
This study aimed to determine the relationships among gut microbiota, primary aldosteronism (PA), and related metabolic disorders.
The study enrolled 13 PA patients, 26 sex-matched primary hypertension patients, and 26 sex-matched healthy controls. Demographic and clinical characteristics such as age, body mass index (BMI), blood aldosterone-renin ratio, blood potassium, blood glucose, blood lipid parameters, and history of diabetes mellitus (DM) were compared between the three groups. The gut microbiota of each participant was examined by 16S rRNA gene sequencing. Spearman correlation analysis was performed to demonstrate the relationship between gut microbiota and clinical characteristics.
BMI and the percentage of DM in PA patients were higher than those in healthy controls ( < 0.05), but not higher than those in primary hypertension patients ( > 0.05). The gut microbiota of healthy controls and primary hypertension patients had a higher alpha diversity level than that of PA patients. PA patients had fewer short-chain fatty acid (SCFA)-producing genera (, , , , and ) and more inflammation-associated genera (, , and ) than healthy controls ( < 0.05). The gut microbiota of PA patients was more inclined to encode microbial pathways involved in sugar metabolism, such as starch and sucrose metabolism and fructose and mannose metabolism. Blood potassium was negatively correlated with the relative abundance of ( = -0.364, = 0.023). Diastolic blood pressure (DBP) was positively correlated with ( = 0.386, = 0.015). Systolic blood pressure (SBP) was negatively correlated with ( = -0.349, = 0.030).
The alteration of gut microbiota in PA patients, especially bacteria and pathways involved in inflammation, SCFAs, and sugar metabolism, may be associated with chronic metabolic disorders.
本研究旨在探讨肠道微生物群、原发性醛固酮增多症（PA）和相关代谢紊乱之间的关系。
本研究纳入了 13 名 PA 患者、26 名性别匹配的原发性高血压患者和 26 名性别匹配的健康对照者。比较三组患者的年龄、体重指数（BMI）、血醛固酮-肾素比值、血钾、血糖、血脂参数以及糖尿病（DM）病史等人口学和临床特征。通过 16S rRNA 基因测序检测每位参与者的肠道微生物群。采用 Spearman 相关分析显示肠道微生物群与临床特征之间的关系。
PA 患者的 BMI 和糖尿病患病率高于健康对照者（均 ＜0.05），但低于原发性高血压患者（均 ＞0.05）。健康对照者和原发性高血压患者的肠道微生物群 α 多样性水平高于 PA 患者。PA 患者产生短链脂肪酸（SCFA）的属（、、、和 ）较少，与炎症相关的属（、和 ）较多，与健康对照者相比差异有统计学意义（均 ＜0.05）。PA 患者的肠道微生物群更倾向于编码与糖代谢相关的微生物途径，如淀粉和蔗糖代谢以及果糖和甘露糖代谢。血钾与相对丰度呈负相关（ ＝-0.364， ＝0.023）。舒张压（DBP）与呈正相关（ ＝0.386， ＝0.015）。收缩压（SBP）与呈负相关（ ＝-0.349， ＝0.030）。
PA 患者肠道微生物群的改变，尤其是与炎症、SCFA 和糖代谢相关的细菌和途径的改变，可能与慢性代谢紊乱有关。
