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基于胸部 CT 图像的新冠病毒(Covid-19)筛查的新型优化卷积神经网络(CNN)集成与动态选择技术。

Novel ensemble of optimized CNN and dynamic selection techniques for accurate Covid-19 screening using chest CT images.

机构信息

Department of Information and Communication Technology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, India.

Department of Computer Science and Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, India.

出版信息

Comput Biol Med. 2021 Oct;137:104835. doi: 10.1016/j.compbiomed.2021.104835. Epub 2021 Sep 6.

Abstract

The world is significantly affected by infectious coronavirus disease (covid-19). Timely prognosis and treatment are important to control the spread of this infection. Unreliable screening systems and limited number of clinical facilities are the major hurdles in controlling the spread of covid-19. Nowadays, many automated detection systems based on deep learning techniques using computed tomography (CT) images have been proposed to detect covid-19. However, these systems have the following drawbacks: (i) limited data problem poses a major hindrance to train the deep neural network model to provide accurate diagnosis, (ii) random choice of hyperparameters of Convolutional Neural Network (CNN) significantly affects the classification performance, since the hyperparameters have to be application dependent and, (iii) the generalization ability using CNN classification is usually not validated. To address the aforementioned issues, we propose two models: (i) based on a transfer learning approach, and (ii) using novel strategy to optimize the CNN hyperparameters using Whale optimization-based BAT algorithm + AdaBoost classifier built using dynamic ensemble selection techniques. According to our second method depending on the characteristics of test sample, the classifier is chosen, thereby reducing the risk of overfitting and simultaneously produced promising results. Our proposed methodologies are developed using 746 CT images. Our method obtained a sensitivity, specificity, accuracy, F-1 score, and precision of 0.98, 0.97, 0.98, 0.98, and 0.98, respectively with five-fold cross-validation strategy. Our developed prototype is ready to be tested with huge chest CT images database before its real-world application.

摘要

世界受到传染性冠状病毒病 (COVID-19) 的严重影响。及时的预后和治疗对于控制这种感染的传播非常重要。不可靠的筛选系统和有限的临床设施是控制 COVID-19 传播的主要障碍。如今,已经提出了许多基于深度学习技术的自动化检测系统,使用计算机断层扫描 (CT) 图像来检测 COVID-19。然而,这些系统存在以下缺点:(i) 有限的数据问题对训练深度神经网络模型以提供准确诊断构成了主要障碍,(ii) 卷积神经网络 (CNN) 的超参数的随机选择会显著影响分类性能,因为超参数必须依赖于应用程序,以及 (iii) 使用 CNN 分类的泛化能力通常未得到验证。为了解决上述问题,我们提出了两种模型:(i) 基于迁移学习方法,和 (ii) 使用新颖的策略通过鲸鱼优化蝙蝠算法优化 CNN 超参数,使用动态集成选择技术构建自适应提升分类器。根据我们的第二种方法,根据测试样本的特点,选择分类器,从而降低过度拟合的风险,同时产生有希望的结果。我们的建议方法是使用 746 张 CT 图像开发的。我们的方法在五重交叉验证策略下获得了 0.98、0.97、0.98、0.98 和 0.98 的灵敏度、特异性、准确性、F1 分数和精度。我们开发的原型已经准备好与庞大的胸部 CT 图像数据库一起进行测试,然后再进行实际应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d31/8418990/13fef33b277d/gr1_lrg.jpg

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