Huang Jianghong, Zhang Jun, Xiong Jianyi, Sun Shuqing, Xia Jiang, Yang Lei, Liang Yujie
Department of Orthopedics, Shenzhen Second People's Hospital (First Affiliated Hospital of Shenzhen University, Health Science Center), Shenzhen 518035, China.
Tsinghua University Shenzhen International Graduate School, Class 9 of 2020 Engineering Ph.D., Shenzhen 518055, China.
Stem Cells Int. 2021 Sep 14;2021:1285087. doi: 10.1155/2021/1285087. eCollection 2021.
Wound healing and regeneration are a dynamic and complex process that requires a collaborative effort between growth factors, epidermal cells, dermal cells, extracellular matrix, and vessels local to the wound area. Mesenchymal stem cells participate in the recruitment site, mainly by releasing secretory factors and matrix proteins to promote wound healing. Stem cell-derived nanovesicles (CDNs), including microvesicles, exosomes, and exosome mimetics, contain most of the biologically active substances of their parent cells and have similar effects. CDNs can shuttle various proteins, messenger RNAs, and microRNAs to regulate the activity of receptor cells, and they play important roles in skin wound healing. This article reviews recent research progress on CDNs for wound repair. We summarize current knowledge on how CDNs regulate immunity, fibroblast activity, angiogenesis, and scar formation in the wound healing process. This review can help researchers explore new treatment strategies to enhance the therapeutic efficacy of CDNs, which have a promising future as naturally cell-free therapies.
伤口愈合与再生是一个动态且复杂的过程，需要生长因子、表皮细胞、真皮细胞、细胞外基质以及伤口局部血管之间的协同作用。间充质干细胞主要通过释放分泌因子和基质蛋白来促进伤口愈合，从而参与到募集部位。干细胞衍生的纳米囊泡（CDNs），包括微泡、外泌体和外泌体模拟物，包含了其亲本细胞的大部分生物活性物质，并具有类似的作用。CDNs 可以转运各种蛋白质、信使核糖核酸和微小核糖核酸来调节受体细胞的活性，它们在皮肤伤口愈合中发挥着重要作用。本文综述了 CDNs 在伤口修复方面的最新研究进展。我们总结了目前关于 CDNs 在伤口愈合过程中如何调节免疫、成纤维细胞活性、血管生成和瘢痕形成的知识。这篇综述有助于研究人员探索新的治疗策略，以提高 CDNs 的治疗效果，作为天然无细胞疗法，CDNs 有着广阔的前景。
