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印度尼西亚儿童粪便中的物种水平组成及其属与他们母亲的不同。

The Species-Level Composition of the Fecal and Genera in Indonesian Children Differs from That of Their Mothers.

作者信息

Ding Mengfan, Yang Bo, Khine Wei Wei Thwe, Lee Yuan-Kun, Rahayu Endang Sutriswati, Ross R Paul, Stanton Catherine, Zhao Jianxin, Zhang Hao, Chen Wei

机构信息

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

出版信息

Microorganisms. 2021 Sep 21;9(9):1995. doi: 10.3390/microorganisms9091995.

DOI:10.3390/microorganisms9091995
PMID:34576890
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8467263/
Abstract

The infant gut microbiota plays a critical role in early life growth and derives mainly from maternal gut and breast milk. This study aimed to analyze the differences in the gut microbiota, namely and communities at species level among breast milk as well as maternal and infant feces at different time points after delivery. Fifty-one mother-infant pairs from Indonesia were recruited, and the breast milk and maternal and infant feces were collected and analyzed by high throughput sequencing (16S rRNA, groEL and groEL genes). PCoA results showed bacterial composition was different among breast milk and maternal and infant feces within the first two years. The abundance of and were significantly higher in infant feces compared to their maternal feces from birth to two years of age, and maternal breast milk within six months after birth ( 0.05), whereas the abundance of , , and was higher in maternal feces compared to that in breast milk within six months and infant feces within one year after birth, respectively ( 0.05). The relative abundances of and was higher and lower in infant feces compared to that in maternal feces only between one and two years of age, respectively ( 0.05). For community at species level, and were identified in all samples. However, the profile of was different between maternal and infant feces at different ages. The relative abundances of and were higher in maternal feces compared to those in infant feces from birth to one year of age ( 0.05), while the relative abundances of subsp. and were higher in infant feces compared to those in maternal feces beyond three months, and the relative abundance of was only higher in infant feces between three and six months ( 0.05). For community, showed higher relative abundance in infant feces when the infant was younger than one year of age ( 0.05). This study showed bacterial composition at the genus level and and communities at the species level were stage specific in maternal breast milk as well as and maternal and infant feces.

摘要

婴儿肠道微生物群在生命早期生长中起着关键作用，主要来源于母体肠道和母乳。本研究旨在分析产后不同时间点母乳、母体粪便和婴儿粪便中肠道微生物群（即物种水平上的 和 群落）的差异。招募了51对来自印度尼西亚的母婴对，收集母乳、母体和婴儿粪便，并通过高通量测序（16S rRNA、 groEL和 groEL基因）进行分析。主坐标分析（PCoA）结果显示，在出生后的头两年内，母乳、母体粪便和婴儿粪便中的细菌组成有所不同。从出生到两岁，以及出生后六个月内的母体母乳中，婴儿粪便中 和 的丰度显著高于母体粪便（ 0.05），而出生后六个月内的母体粪便中 、 和 的丰度分别高于母乳和出生后一年内的婴儿粪便（ 0.05）。仅在一岁至两岁之间，婴儿粪便中 和 的相对丰度分别高于和低于母体粪便（ 0.05）。对于物种水平上的 群落，所有样本中均鉴定出 和 。然而，不同年龄的母体和婴儿粪便中 的分布情况不同。从出生到一岁，母体粪便中 和 的相对丰度高于婴儿粪便（ 0.05），而三个月后婴儿粪便中 亚种 和 的相对丰度高于母体粪便，且仅在三个月至六个月之间婴儿粪便中 的相对丰度较高（ 0.05）。对于 群落，婴儿一岁前婴儿粪便中的 相对丰度较高（ 0.05）。本研究表明，母体母乳、母体和婴儿粪便中属水平的细菌组成以及物种水平上的 和 群落具有阶段特异性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/fe00d069e6da/microorganisms-09-01995-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/14c0d3092061/microorganisms-09-01995-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/9d4fe9942514/microorganisms-09-01995-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/f26434fd00e2/microorganisms-09-01995-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/3d77ac99da08/microorganisms-09-01995-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/cd3ed8600314/microorganisms-09-01995-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/7a67bcb91f3b/microorganisms-09-01995-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/12bd93f0e36a/microorganisms-09-01995-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/3dab4348df5b/microorganisms-09-01995-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/fe00d069e6da/microorganisms-09-01995-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/14c0d3092061/microorganisms-09-01995-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/9d4fe9942514/microorganisms-09-01995-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/f26434fd00e2/microorganisms-09-01995-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/3d77ac99da08/microorganisms-09-01995-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/cd3ed8600314/microorganisms-09-01995-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/7a67bcb91f3b/microorganisms-09-01995-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/12bd93f0e36a/microorganisms-09-01995-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/3dab4348df5b/microorganisms-09-01995-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ed/8467263/fe00d069e6da/microorganisms-09-01995-g009.jpg

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