Zhou Qian, Ju Lin-Ling, Ji Xiang, Cao Ya-Li, Shao Jian-Guo, Chen Lin
Medical School of Nantong University, Nantong Third People's Hospital, Nantong, Jiangsu, People's Republic of China.
Nantong Institute of Liver Disease, Nantong Third People's Hospital, Nantong University, Nantong, Jiangsu, People's Republic of China.
Cancer Manag Res. 2021 Sep 21;13:7325-7337. doi: 10.2147/CMAR.S330228. eCollection 2021.
The incidence and mortality of cancer are increasing each year. At present, the sensitivity and specificity of the blood biomarkers that were used in clinical practice are low, which make the detection rate of cancer decrease. With advances in bioinformatics and technology, some non-coding RNA as biomarkers can be easily detected through some traditional and new technologies. Circular RNAs (circRNAs) are non-coding RNAs, that is, they do not encode proteins, and have important regulatory functions. CircRNAs can remain stable in bodily fluids, such as in saliva, blood, urine, and especially plasma. The difference in the expression of plasma circRNAs between cancer patients and normal people may suggest that plasma circRNAs may play an important role in the occurrence and development of cancer. In this review, we summarized the clinical effect of plasma circRNAs in several high-incidence cancers. CircRNAs may be effective biomarkers for tumour diagnosis, treatment selection and prognosis evaluation.
癌症的发病率和死亡率每年都在上升。目前，临床实践中使用的血液生物标志物的敏感性和特异性较低，这使得癌症的检出率下降。随着生物信息学和技术的进步，一些作为生物标志物的非编码RNA可以通过一些传统和新技术轻松检测到。环状RNA（circRNAs）是非编码RNA，即它们不编码蛋白质，但具有重要的调控功能。CircRNAs可以在体液中保持稳定，如唾液、血液、尿液，尤其是血浆中。癌症患者与正常人血浆circRNAs表达的差异可能表明血浆circRNAs在癌症的发生和发展中可能起重要作用。在这篇综述中，我们总结了血浆circRNAs在几种高发病率癌症中的临床作用。CircRNAs可能是肿瘤诊断、治疗选择和预后评估的有效生物标志物。
