Yan Zhi, Wang Hua, Mu Lan, Hu Zhi-De, Zheng Wen-Qi
Department of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, China.
Department of Parasitology, the College of Basic Medical Sciences of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, China.
World J Clin Cases. 2021 Sep 6;9(25):7311-7318. doi: 10.12998/wjcc.v9.i25.7311.
Extracellular vesicles (EVs) are cystic vesicles naturally released by most mammalian cells and bacteria. EV contents include proteins, lipids, and nucleic acids. EVs can act as messengers to transmit a variety of molecules to recipient cells and thus play important regulatory roles in intercellular signal transduction. EVs, released by either a host cell or a pathogen, can carry pathogen-associated antigens and thus act as modulators of immune responses. EVs derived from ()-infected cells can regulate the innate immune response through various pathways, such as regulating the release of inflammatory cytokines. In addition, EVs can mediate antigen presentation and regulate the adaptive immune response by transmitting immunoregulatory molecules to T helper cells. In this review, we summarize the regulatory roles of EVs in the immune response against .
细胞外囊泡（EVs）是大多数哺乳动物细胞和细菌自然释放的囊性囊泡。EVs的内容物包括蛋白质、脂质和核酸。EVs可作为信使将多种分子传递给受体细胞，从而在细胞间信号转导中发挥重要调节作用。由宿主细胞或病原体释放的EVs可携带病原体相关抗原，因此可作为免疫反应的调节剂。源自（）感染细胞的EVs可通过多种途径调节先天免疫反应，如调节炎性细胞因子的释放。此外，EVs可介导抗原呈递，并通过将免疫调节分子传递给辅助性T细胞来调节适应性免疫反应。在本综述中，我们总结了EVs在针对（）的免疫反应中的调节作用。
