Gras-Valentí Paula, Chico-Sánchez Pablo, Algado-Sellés Natividad, Gimeno-Gascón María Adelina, Mora-Muriel Juan Gabriel, Jiménez-Sepúlveda Natali Juliet, Gómez-Sotero Isel Lilibeth, Montiel-Higuero Inés, Sánchez-Payá José, Rodríguez-Díaz Juan Carlos
Unidad de Epidemiología, Servicio de Medicina Preventiva, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, España.
Servicio de Microbiología, Servicio de Medicina Preventiva, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, España.
Enferm Infecc Microbiol Clin. 2021 Aug-Sep;39(7):319-325. doi: 10.1016/j.eimc.2020.09.015. Epub 2020 Oct 14.
Estimate IgG antibody prevalence against SARS-CoV-2 in healthcare personnel (HCP) of a healthcare department (HD).
Prevalence study. The presence of IgG antibodies against SARS-CoV-2 was determined in HCP of the HD. Enzyme linked immunosorbent assays (ELISA) tests were used. Field work took place from April 24, 2020 to May 8, 2020. The age, sex, occupation (physician, nurse, etc.) and the work area (Primary Care, Emergency Room, etc.) were gathered. The IgG antibody prevalence was then calculated with its 95% confidence interval (95% CI). To study the association between HCP characteristics and the presence IgG the Chi Square test was used, and to study the magnitude of association, the Odds Ratio (95% CI) was calculated.
Of the 4813 HCP in the HD, 4179 (87,1%) participated. Of these, 73,3% (3065) were women and 26,7% (1114) men. The global prevalence of IgG antibodies against SARS-CoV-2 was 6,6% (95% CI: 5,8-7,3). There were statistically significant differences depending on the occupation, from 8,7% (95% CI: 6,9-10,6) on medics down to 3,2% (95% CI: 1,0-8,0) on personnel not associated with health care. The other characteristics did not associate significantly to antibody presence against SARS-CoV-2.
The SARS-CoV-2 infection frequency in HCP is similar to the estimated in the general population for big cities in Spain. This highlights the effectiveness of the infection control and prevention programme in this healthcare department targeted at healthcare personnel.
估算某医疗部门（HD）医护人员（HCP）中针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的IgG抗体流行率。
进行患病率研究。在HD的HCP中测定针对SARS-CoV-2的IgG抗体的存在情况。采用酶联免疫吸附测定（ELISA）试验。现场工作于2020年4月24日至2020年5月8日进行。收集年龄、性别、职业（医生、护士等）和工作区域（初级保健、急诊室等）信息。然后计算IgG抗体流行率及其95%置信区间（95%CI）。为研究HCP特征与IgG存在之间的关联，使用卡方检验，并计算比值比（95%CI）以研究关联强度。
HD的4813名HCP中，4179名（87.1%）参与。其中，73.3%（3065名）为女性，26.7%（1114名）为男性。针对SARS-CoV-2的IgG抗体总体流行率为6.6%（95%CI：5.8 - 7.3）。根据职业不同存在统计学显著差异，从医务人员的8.7%（95%CI：6.9 - 10.6）到非医疗保健相关人员的3.2%（95%CI：1.0 - 8.0）。其他特征与针对SARS-CoV-2的抗体存在无显著关联。
HCP中SARS-CoV-2感染频率与西班牙大城市一般人群的估计值相似。这凸显了该医疗部门针对医护人员的感染控制与预防计划的有效性。
