对抗尼帕病毒的最新进展。
Recent advances in combating Nipah virus.
作者信息
Johnson Kendra, Vu Michelle, Freiberg Alexander N
机构信息
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
出版信息
Fac Rev. 2021 Sep 29;10:74. doi: 10.12703/r/10-74. eCollection 2021.
Over the past 20 years, Nipah virus (NiV) has emerged as a significant, highly pathogenic bat-borne paramyxovirus causing severe respiratory disease and encephalitis in humans, and human-to-human transmission has been demonstrated in multiple outbreaks. In addition to causing serious illness in humans, NiV is a zoonotic pathogen capable of infecting a wide range of other mammalian species, including pigs and horses. While NiV has caused less than 700 human cases since its discovery in 1998/1999, the involvement of intermediate agricultural hosts can result in significant economic consequences. Owing to the severity of disease, capacity for human-to-human transmission, zoonotic potential, and lack of available approved therapeutic treatment options, NiV has been listed by the World Health Organization in their Blueprint list of priority pathogens as one of the eight most dangerous pathogens to monitor and prepare countermeasures to prevent a pandemic. Here, we discuss progress towards the development of therapeutic measures for the treatment of NiV infection and disease.
在过去20年里，尼帕病毒（NiV）已成为一种重要的、高致病性的蝙蝠传播副粘病毒，可导致人类严重的呼吸道疾病和脑炎，并且在多次疫情中已证实存在人际传播。除了在人类中引发严重疾病外，尼帕病毒还是一种人畜共患病原体，能够感染包括猪和马在内的多种其他哺乳动物物种。自1998年/1999年被发现以来，虽然尼帕病毒导致的人类病例不到700例，但中间农业宿主的参与可能会造成重大经济后果。由于疾病的严重性、人际传播能力、人畜共患病潜力以及缺乏可用的经批准的治疗选择，尼帕病毒已被世界卫生组织列入其重点病原体蓝图清单，成为需要监测并制定应对措施以预防大流行的八大最危险病原体之一。在此，我们讨论尼帕病毒感染和疾病治疗措施研发方面的进展。
Zotero 插件