Boutot Maegan E, Whitcomb Brian W, Abdelouahab Nadia, Baccarelli Andrea A, Boivin Amélie, Caku Artuela, Gillet Virginie, Martinez Guillaume, Pasquier Jean-Charles, Zhu Jiping, Takser Larissa, St-Cyr Lindsay, Suvorov Alexander
Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Department of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Sherbrooke University, Sherbrooke, QC J1H 5N4, Canada.
Metabolites. 2021 Sep 28;11(10):657. doi: 10.3390/metabo11100657.
Animal studies have shown that developmental exposures to polybrominated diphenyl ethers (PBDE) permanently affect blood/liver balance of lipids. No human study has evaluated associations between in utero exposures to persistent organic pollutants (POPs) and later life lipid metabolism. In this pilot, maternal plasma levels of PBDEs (BDE-47, BDE-99, BDE-100, and BDE-153) and polychlorinated biphenyls (PCB-138, PCB-153, and PCB-180) were determined at delivery in participants of GESTation and Environment (GESTE) cohort. Total cholesterol (TCh), triglycerides (TG), low- and high-density lipoproteins (LDL-C and HDL-C), total lipids (TL), and PBDEs were determined in serum of 147 children at ages 6-7. General linear regression was used to estimate the relationship between maternal POPs and child lipid levels with adjustment for potential confounders, and adjustment for childhood POPs. In utero BDE-99 was associated with lower childhood levels of TG ( = 0.003), and non-significantly with HDL-C ( = 0.06) and TL ( = 0.07). Maternal PCB-138 was associated with lower childhood levels of TG ( = 0.04), LDL-C ( = 0.04), and TL ( = 0.02). Our data indicate that in utero exposures to POPs may be associated with long lasting decrease in circulating lipids in children, suggesting increased lipid accumulation in the liver, a mechanism involved in NAFLD development, consistent with previously reported animal data.
动物研究表明，发育期接触多溴二苯醚（PBDE）会永久性地影响血液/肝脏的脂质平衡。尚无人体研究评估子宫内接触持久性有机污染物（POPs）与晚年脂质代谢之间的关联。在这项初步研究中，测定了妊娠与环境（GESTE）队列参与者分娩时母体血浆中多溴二苯醚（BDE - 47、BDE - 99、BDE - 100和BDE - 153）以及多氯联苯（PCB - 138、PCB - 153和PCB - 180）的水平。测定了147名6 - 7岁儿童血清中的总胆固醇（TCh）、甘油三酯（TG）、低密度和高密度脂蛋白（LDL - C和HDL - C）、总脂质（TL）以及多溴二苯醚水平。采用一般线性回归来估计母体持久性有机污染物与儿童脂质水平之间的关系，并对潜在混杂因素以及儿童期持久性有机污染物进行校正。子宫内接触BDE - 99与儿童期较低的TG水平相关（P = 0.003），与HDL - C（P = 0.06）和TL（P = 0.07）的相关性不显著。母体PCB - 138与儿童期较低的TG水平（P = 0.04）、LDL - C（P = 0.04）和TL水平（P = 0.02）相关。我们的数据表明，子宫内接触持久性有机污染物可能与儿童循环脂质的长期减少有关，提示肝脏脂质蓄积增加，这是参与非酒精性脂肪性肝病（NAFLD）发展的一种机制，与先前报道的动物数据一致。
