Bernardinelli L, de Marco R, Tinelli C
Br J Ind Med. 1987 Mar;44(3):187-91. doi: 10.1136/oem.44.3.187.
The purpose of the study was to describe the mortality experience of an Italian cohort of rubber workers and an attempt was made to identify any occupational cancer hazards that might currently be affecting men employed in this type of work. A total of 4917 male workers who first started working in a large rubber factory between 1962 and 1972 have been followed up until 31 January 1983. The number of deaths from all causes and from malignant neoplasms was determined and compared with the expected number of deaths calculated from mortality rates for the province in which the population of the plant lived. Mortality from all causes was 85% of that expected. A slight overall excess of deaths from cancer (SMR = 119) was found; this was entirely due to the excess mortality in the 35-44 age group. In order further to evaluate the possible existence of a cancer risk SMRs were analysed by duration of exposure, time since first exposure, and for specific sites of cancer. A trend in SMR with duration of exposure was found for employees with 10 years of follow up or more. A high risk for some tumour sites emerged.
该研究的目的是描述一组意大利橡胶工人的死亡情况,并试图确定目前可能影响从事此类工作的男性的任何职业性癌症风险因素。共有4917名男性工人,他们于1962年至1972年间首次开始在一家大型橡胶厂工作,一直随访至1983年1月31日。确定了所有原因和恶性肿瘤导致的死亡人数,并与根据该厂所在省份的死亡率计算出的预期死亡人数进行了比较。所有原因导致的死亡率为预期死亡率的85%。发现癌症死亡总体略有超额(标准化死亡比=119);这完全是由于35-44岁年龄组的超额死亡率所致。为了进一步评估癌症风险的可能存在情况,按接触时间、首次接触后的时间以及特定癌症部位分析了标准化死亡比。对于随访10年或更长时间的员工,发现标准化死亡比随接触时间有一定趋势。出现了某些肿瘤部位的高风险情况。