手术切除肝内胆管细胞癌后，精氨酸酶-1 和磷脂酰聚糖-3 表达水平的预后价值。
The prognostic value of arginase-1 and glypican-3 expression levels in patients after surgical intrahepatic cholangiocarcinoma resection.
机构信息
Department of Hepatobiliary Surgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, 450003, China.
Department of Hepatobiliary Surgery, Medical College of Zhengzhou University, Zhengzhou, China.
出版信息
World J Surg Oncol. 2021 Oct 29;19(1):316. doi: 10.1186/s12957-021-02426-9.
BACKGROUND
The aim of this study was to investigate the prognostic value of arginase-1 (Arg-1) and glypican-3 (GPC-3) in patients with intrahepatic cholangiocarcinoma (ICC).
METHODS
Two hundred and thirty-seven patients with ICC were included in this study. All patients had undergone radical surgery and had complete clinical information. Immunohistochemistry was used to assess the levels of Arg-1 and GPC-3 in ICC tissues. Univariate and multivariate analyses were conducted to identify independent risk factors in ICC. The relationship between Arg-1 and GPC-3 levels and patient survival was determined using the Kaplan-Meier method.
RESULTS
High Arg-1 and GPC-3 expression levels were associated with poor prognosis in patients with ICC, and they could be as new prognostic biomarkers in ICC.
CONCLUSION
Arg-1 and GPC-3 can serve as independent prognostic biomarkers in ICC.
背景
本研究旨在探讨精氨酸酶-1（Arg-1）和磷脂酰聚糖-3（GPC-3）在肝内胆管癌（ICC）患者中的预后价值。
方法
本研究纳入 237 例 ICC 患者。所有患者均接受根治性手术，并具有完整的临床资料。免疫组织化学法检测 ICC 组织中 Arg-1 和 GPC-3 的水平。采用单因素和多因素分析确定 ICC 的独立危险因素。采用 Kaplan-Meier 法确定 Arg-1 和 GPC-3 水平与患者生存的关系。
结果
Arg-1 和 GPC-3 高表达与 ICC 患者预后不良相关，它们可能成为 ICC 的新预后生物标志物。
结论
Arg-1 和 GPC-3 可作为 ICC 的独立预后生物标志物。
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