Hu Shoushan, Alimire Alifu, Lai Yancheng, Hu Haonan, Chen Zhuo, Li Yi
State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Front Med (Lausanne). 2021 Oct 26;8:740710. doi: 10.3389/fmed.2021.740710. eCollection 2021.
With rapid development in molecular biology techniques and a greater understanding of cancer pathogenesis, the growing attention has been concentrated on cancer gene therapy, with numerous articles on this topic published in recent 5 years. However, there is lacking a bibliometric analysis of research on cancer gene therapy. Therefore, the aim of the present study was to conduct a bibliometric analysis to provide the trends and frontiers of research on cancer gene therapy during 2016-2020. We utilized CiteSpace 5.7.R5 software to conduct a bibliometric analysis of publications on cancer gene therapy published during 2016-2020. The bibliometric records were obtained from the Web of Science Core Collection. A total of 4,392 papers were included in the bibliometric analysis. Materials Science and Nanoscience and Nanotechnology took an increasing part in the field of cancer gene therapy. Additionally, WANG W was the most productive author, while ZHANG Y ranked top in terms of citations. Harvard Medical School and Sichuan University ranked top in the active institutions. was identified as the core journal in the field of cancer gene therapy. "Ovarian cancer" was found to be the latest keyword with the strongest burst. The keyword analysis suggested that the top three latest clusters were labeled "gene delivery," "drug delivery," and "gene therapy." In the reference analysis, cluster#2 labeled "gene delivery" held a dominant place considering both the node volume and mean year. The academic attention on cancer gene therapy was growing at a dramatically high speed. Materials Science and Nanoscience and Nanotechnology might become promising impetus for the development of this field. "Gene delivery" was thought to best reflect the research frontier on cancer gene therapy. The top-cited articles on gene delivery were focused on several novel non-viral vectors due to their specialty compared with viral vectors. "Ovarian cancer" was likely to be the potential research direction. These findings would help medical workers conduct further investigations on cancer gene therapy.
随着分子生物学技术的快速发展以及对癌症发病机制的深入了解，癌症基因治疗受到越来越多的关注，近五年发表了大量关于该主题的文章。然而，目前缺乏对癌症基因治疗研究的文献计量分析。因此，本研究旨在进行文献计量分析，以呈现2016 - 2020年期间癌症基因治疗研究的趋势和前沿。我们使用CiteSpace 5.7.R5软件对2016 - 2020年发表的癌症基因治疗相关文献进行文献计量分析。文献计量记录来自Web of Science核心合集。共有4392篇论文纳入文献计量分析。材料科学以及纳米科学与纳米技术在癌症基因治疗领域的参与度不断增加。此外，王W是发文量最多的作者，而张Y在被引次数方面排名第一。哈佛医学院和四川大学在活跃机构中排名靠前。被确定为癌症基因治疗领域的核心期刊。“卵巢癌”被发现是最新且爆发强度最大的关键词。关键词分析表明，最新的三大聚类分别标记为“基因递送”“药物递送”和“基因治疗”。在参考文献分析中，聚类#2标记的“基因递送”在节点数量和平均年份方面都占据主导地位。对癌症基因治疗的学术关注度正以极高的速度增长。材料科学以及纳米科学与纳米技术可能成为该领域发展的有前景的推动力。“基因递送”被认为最能反映癌症基因治疗的研究前沿。关于基因递送的高被引文章主要集中在几种新型非病毒载体上，因为它们与病毒载体相比具有特殊性。“卵巢癌”可能是潜在的研究方向。这些发现将有助于医学工作者对癌症基因治疗进行进一步研究。
