Chen Shanshan, Fang Yi, Sun Lingyu, He Ruonan, He Beihui, Zhang Shuo
The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China.
The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Front Oncol. 2021 Oct 27;11:762752. doi: 10.3389/fonc.2021.762752. eCollection 2021.
Colorectal cancer (CRC), being one of the most commonly diagnosed cancers worldwide, endangers human health. Because the pathological mechanism of CRC is not fully understood, there are many challenges in the prevention, diagnosis, and treatment of this disease. Long non-coding RNAs (lncRNAs) have recently drawn great attention for their potential roles in the different stages of CRC formation, invasion, and progression, including regulation of molecular signaling pathways, apoptosis, autophagy, angiogenesis, tumor metabolism, immunological responses, cell cycle, and epithelial-mesenchymal transition (EMT). This review aims to discuss the potential mechanisms of several oncogenic lncRNAs, as well as several suppressor lncRNAs, in CRC occurrence and development to aid in the discovery of new methods for CRC diagnosis, treatment, and prognosis assessment.
结直肠癌（CRC）是全球最常见的诊断癌症之一，危害人类健康。由于CRC的病理机制尚未完全了解，该疾病的预防、诊断和治疗面临诸多挑战。长链非编码RNA（lncRNAs）最近因其在CRC形成、侵袭和进展的不同阶段的潜在作用而备受关注，包括对分子信号通路、细胞凋亡、自噬、血管生成、肿瘤代谢、免疫反应、细胞周期和上皮-间质转化（EMT）的调节。本综述旨在探讨几种致癌lncRNAs以及几种抑癌lncRNAs在CRC发生发展中的潜在机制，以助力发现CRC诊断、治疗和预后评估的新方法。
