Zamami Yoshito, Hamano Hirofumi, Niimura Takahiro, Aizawa Fuka, Yagi Kenta, Goda Mitsuhiro, Izawa-Ishizawa Yuki, Ishizawa Keisuke
Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan.
Front Pharmacol. 2021 Nov 1;12:752174. doi: 10.3389/fphar.2021.752174. eCollection 2021.
Drug repositioning is a drug discovery strategy in which an existing drug is utilized as a therapeutic agent for a different disease. As information regarding the safety, pharmacokinetics, and formulation of existing drugs is already available, the cost and time required for drug development is reduced. Conventional drug repositioning has been dominated by a method involving the search for candidate drugs that act on the target molecules of an organism in a diseased state through basic research. However, recently, information hosted on medical information and life science databases have been used in translational research to bridge the gap between basic research in drug repositioning and clinical application. Here, we review an example of drug repositioning wherein candidate drugs were found and their mechanisms of action against a novel therapeutic target were identified via a basic research method that combines the findings retrieved from various medical and life science databases.
药物重新定位是一种药物发现策略，即利用现有药物作为治疗另一种疾病的治疗剂。由于已有关于现有药物安全性、药代动力学和制剂的信息，因此降低了药物开发所需的成本和时间。传统的药物重新定位一直以一种方法为主，该方法涉及通过基础研究寻找作用于患病状态下生物体靶分子的候选药物。然而，最近，医学信息和生命科学数据库中的信息已被用于转化研究，以弥合药物重新定位的基础研究与临床应用之间的差距。在此，我们回顾一个药物重新定位的例子，其中通过一种基础研究方法发现了候选药物，并确定了它们针对新治疗靶点的作用机制，该方法结合了从各种医学和生命科学数据库中检索到的结果。
