Lin Chengxiong, Wang Yaocheng, Huang Zhengyu, Wu Tingting, Xu Weikang, Wu Wenming, Xu Zhibiao
National Engineering Research Center for Healthcare Devices, Guangdong Provincial Key Laboratory of Medical Electronic Instruments and Polymer Products, Guangdong Medical Device Research Institute, Guangzhou 510500, China.
School of Railway Tracks and Transportation, Wuyi University, Jiangmen 529020, China.
Int J Bioprint. 2021 Oct 13;7(4):426. doi: 10.18063/ijb.v7i4.426. eCollection 2021.
Conventional bone repair scaffolds can no longer meet the high standards and requirements of clinical applications in terms of preparation process and service performance. Studies have shown that the diversity of filament structures of implantable scaffolds is closely related to their overall properties (mechanical properties, degradation properties, and biological properties). To better elucidate the characteristics and advantages of different filament structures, this paper retrieves and summarizes the state of the art in the filament structure of the three-dimensional (3D) bioprinted biodegradable bone repair scaffolds, mainly including single-layer structure, double-layer structure, hollow structure, core-shell structure and bionic structures. The eximious performance of the novel scaffolds was discussed from different aspects (material composition, ink configuration, printing parameters, etc.). Besides, the additional functions of the current bone repair scaffold, such as chondrogenesis, angiogenesis, anti-bacteria, and anti-tumor, were also concluded. Finally, the paper prospects the future material selection, structural design, functional development, and performance optimization of bone repair scaffolds.
传统的骨修复支架在制备工艺和使用性能方面已无法满足临床应用的高标准和要求。研究表明，可植入支架的丝状结构多样性与其整体性能（力学性能、降解性能和生物学性能）密切相关。为了更好地阐明不同丝状结构的特点和优势，本文检索并总结了三维（3D）生物打印可降解骨修复支架丝状结构的研究现状，主要包括单层结构、双层结构、中空结构、核壳结构和仿生结构。从不同方面（材料组成、墨水配置、打印参数等）讨论了新型支架的优异性能。此外，还总结了当前骨修复支架的附加功能，如软骨生成、血管生成、抗菌和抗肿瘤功能。最后，本文对骨修复支架未来的材料选择、结构设计、功能开发和性能优化进行了展望。
