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3D生物打印可生物降解骨修复支架的细丝结构进展

Advances in Filament Structure of 3D Bioprinted Biodegradable Bone Repair Scaffolds.

作者信息

Lin Chengxiong, Wang Yaocheng, Huang Zhengyu, Wu Tingting, Xu Weikang, Wu Wenming, Xu Zhibiao

机构信息

National Engineering Research Center for Healthcare Devices, Guangdong Provincial Key Laboratory of Medical Electronic Instruments and Polymer Products, Guangdong Medical Device Research Institute, Guangzhou 510500, China.

School of Railway Tracks and Transportation, Wuyi University, Jiangmen 529020, China.

出版信息

Int J Bioprint. 2021 Oct 13;7(4):426. doi: 10.18063/ijb.v7i4.426. eCollection 2021.


DOI:10.18063/ijb.v7i4.426
PMID:34805599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8600304/
Abstract

Conventional bone repair scaffolds can no longer meet the high standards and requirements of clinical applications in terms of preparation process and service performance. Studies have shown that the diversity of filament structures of implantable scaffolds is closely related to their overall properties (mechanical properties, degradation properties, and biological properties). To better elucidate the characteristics and advantages of different filament structures, this paper retrieves and summarizes the state of the art in the filament structure of the three-dimensional (3D) bioprinted biodegradable bone repair scaffolds, mainly including single-layer structure, double-layer structure, hollow structure, core-shell structure and bionic structures. The eximious performance of the novel scaffolds was discussed from different aspects (material composition, ink configuration, printing parameters, etc.). Besides, the additional functions of the current bone repair scaffold, such as chondrogenesis, angiogenesis, anti-bacteria, and anti-tumor, were also concluded. Finally, the paper prospects the future material selection, structural design, functional development, and performance optimization of bone repair scaffolds.

摘要

传统的骨修复支架在制备工艺和使用性能方面已无法满足临床应用的高标准和要求。研究表明,可植入支架的丝状结构多样性与其整体性能(力学性能、降解性能和生物学性能)密切相关。为了更好地阐明不同丝状结构的特点和优势,本文检索并总结了三维(3D)生物打印可降解骨修复支架丝状结构的研究现状,主要包括单层结构、双层结构、中空结构、核壳结构和仿生结构。从不同方面(材料组成、墨水配置、打印参数等)讨论了新型支架的优异性能。此外,还总结了当前骨修复支架的附加功能,如软骨生成、血管生成、抗菌和抗肿瘤功能。最后,本文对骨修复支架未来的材料选择、结构设计、功能开发和性能优化进行了展望。

相似文献

[1]
Advances in Filament Structure of 3D Bioprinted Biodegradable Bone Repair Scaffolds.

Int J Bioprint. 2021-10-13

[2]
Three-dimensional (3D) printed scaffold and material selection for bone repair.

Acta Biomater. 2018-11-24

[3]
Tuning filament composition and microstructure of 3D-printed bioceramic scaffolds facilitate bone defect regeneration and repair.

Regen Biomater. 2021-3-13

[4]
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J Mech Behav Biomed Mater. 2020-4

[5]
3D Bioprinting Photo-Crosslinkable Hydrogels for Bone and Cartilage Repair.

Int J Bioprint. 2021-6-24

[6]
Noninvasive Three-Dimensional and Characterization of Bioprinted Hydrogel Scaffolds Using the X-ray Propagation-Based Imaging Technique.

ACS Appl Mater Interfaces. 2021-6-9

[7]
Nonstoichiometric wollastonite bioceramic scaffolds with core-shell pore struts and adjustable mechanical and biodegradable properties.

J Mech Behav Biomed Mater. 2018-8-21

[8]
[CYTOCOMPATIBILITY AND PREPARATION OF BONE TISSUE ENGINEERING SCAFFOLD BY COMBINING LOW TEMPERATURE THREE DIMENSIONAL PRINTING AND VACUUM FREEZE-DRYING TECHNIQUES].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2016-3

[9]
Current state of fabrication technologies and materials for bone tissue engineering.

Acta Biomater. 2018-9-22

[10]
Extrusion-based 3D printing of ex situ-alloyed highly biodegradable MRI-friendly porous iron-manganese scaffolds.

Acta Biomater. 2021-10-15

引用本文的文献

[1]
Core-shell 3D printed biodegradable calcium phosphate cement-Alginate scaffolds for possible bone regeneration applications.

Front Drug Deliv. 2024-5-17

[2]
Commercially available bioinks and state-of-the-art lab-made formulations for bone tissue engineering: A comprehensive review.

Mater Today Bio. 2024-11-14

[3]
Research on Dual-Phase Composite Forming Process and Platform Construction of Radial Gradient Long Bone Scaffold.

Bioengineering (Basel). 2024-8-27

[4]
Optimizing Filament-Based TCP Scaffold Design for Osteoconduction and Bone Augmentation: Insights from In Vivo Rabbit Models.

J Funct Biomater. 2024-6-25

[5]
Fused Deposition Modeling 3D-Printed Scaffolds for Bone Tissue Engineering Applications: A Review.

Ann Biomed Eng. 2024-5

[6]
Simvastatin-loaded 3D aerogel scaffolds promote bone regeneration.

Biomed Mater Eng. 2024

[7]
characterization of 3D-printed polycaprolactone-hydroxyapatite scaffolds with Voronoi design to advance the concept of scaffold-guided bone regeneration.

Front Bioeng Biotechnol. 2023-10-4

[8]
Experimental study on repair of cartilage defects in the rabbits with GelMA-MSCs scaffold prepared by three-dimensional bioprinting.

Int J Bioprint. 2023-1-5

[9]
Osteoconductivity of bone substitutes with filament-based microarchitectures: Influence of directionality, filament dimension, and distance.

Int J Bioprint. 2022-10-27

[10]
The Dual Effect of 3D-Printed Biological Scaffolds Composed of Diverse Biomaterials in the Treatment of Bone Tumors.

Int J Nanomedicine. 2023

本文引用的文献

[1]
3D Printing of Physical Organ Models: Recent Developments and Challenges.

Adv Sci (Weinh). 2021-9

[2]
Synthesis of a mace-like cellulose nanocrystal@Ag nanosystem via in-situ growth for antibacterial activities of poly-L-lactide scaffold.

Carbohydr Polym. 2021-6-15

[3]
3D bioprinting of hepatocytes: core-shell structured co-cultures with fibroblasts for enhanced functionality.

Sci Rep. 2021-3-4

[4]
3D Bioprinting of Vessel-like Structures with Multilevel Fluidic Channels.

ACS Biomater Sci Eng. 2017-3-13

[5]
Modified hyaluronic acid hydrogels with chemical groups that facilitate adhesion to host tissues enhance cartilage regeneration.

Bioact Mater. 2020-11-29

[6]
Lotus seedpod-inspired internal vascularized 3D printed scaffold for bone tissue repair.

Bioact Mater. 2020-11-27

[7]
Black Bioceramics: Combining Regeneration with Therapy.

Adv Mater. 2020-12

[8]
3D bioprinting dual-factor releasing and gradient-structured constructs ready to implant for anisotropic cartilage regeneration.

Sci Adv. 2020-9-9

[9]
Constructing a Sr-Substituted Surface Hydroxyapatite Hexagon-Like Microarray on 3D-Plotted Hydroxyapatite Scaffold to Regulate Osteogenic Differentiation.

Nanomaterials (Basel). 2020-8-26

[10]
Cryogenic 3D printing of dual-delivery scaffolds for improved bone regeneration with enhanced vascularization.

Bioact Mater. 2020-8-12

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