Marques Mário Pedro, Varela Carla, Mendonça Laura, Cabral Célia
Coimbra Institute for Clinical and Biomedical Research (iCBR), Clinic Academic Center of Coimbra (CACC), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.
Pharmaceutics. 2023 Jun 14;15(6):1724. doi: 10.3390/pharmaceutics15061724.
Atopic dermatitis (AD) is a chronic eczematous inflammatory disease that may arise from environmental, genetic, and immunological factors. Despite the efficacy of current treatment options such as corticosteroids, such approaches are mainly focused on symptom relief and may present certain undesirable side effects. In recent years, isolated natural compounds, oils, mixtures, and/or extracts have gained scientific attention because of their high efficiency and moderate to low toxicity. Despite their promising therapeutic effects, the applicability of such natural healthcare solutions is somewhat limited by their instability, poor solubility, and low bioavailability. Therefore, novel nanoformulation-based systems have been designed to overcome these limitations, thus enhancing the therapeutic potential, by promoting the capacity of these natural drugs to properly exert their action in AD-like skin lesions. To the best of our knowledge, this is the first literature review that has focused on summarizing recent nanoformulation-based solutions loaded with natural ingredients, specifically for the management of AD. We suggest that future studies should focus on robust clinical trials that may confirm the safety and effectiveness of such natural-based nanosystems, thus paving the way for more reliable AD treatments.
特应性皮炎（AD）是一种慢性湿疹性炎症性疾病，可能由环境、遗传和免疫因素引起。尽管目前的治疗方法如皮质类固醇有效，但这些方法主要侧重于缓解症状，可能会出现某些不良副作用。近年来，分离出的天然化合物、油类、混合物和/或提取物因其高效以及中低毒性而受到科学关注。尽管它们具有有前景的治疗效果，但这类天然保健解决方案的适用性在一定程度上受到其不稳定性、低溶解度和低生物利用度的限制。因此，已设计出基于新型纳米制剂的系统来克服这些限制，通过提高这些天然药物在类AD皮肤损伤中正确发挥作用的能力来增强治疗潜力。据我们所知，这是第一篇专注于总结近期基于纳米制剂的、含有天然成分的解决方案（专门用于AD管理）的文献综述。我们建议未来的研究应侧重于强有力的临床试验，以证实这类基于天然物质的纳米系统的安全性和有效性，从而为更可靠的AD治疗铺平道路。
