Merkis Mantvydas, Puišo Judita, Adliene Diana, Laurikaitiene Jurgita
Department of Physics, Kaunas University of Technology, Studentų str. 50, 51368 Kaunas, Lithuania.
Polymers (Basel). 2021 Nov 13;13(22):3925. doi: 10.3390/polym13223925.
Polymer gels and films, due to their near equivalence to biological tissue, are amongst the most promising future dosimetry tools for medical applications. The application of polymer dose gels is limited by the sensitivity of dose readout methods and dose gel properties. It is a challenge to find suitable dosimeters for registration of doses delivered to the target by orthovoltage therapy units. The application of metal-particle-enriched polymer composites for dose registration in X-ray therapy might be an elegant solution, especially if recent dose-reading technologies exploring advantages of different physical phenomena are involved. In this work, X-rays from the orthovoltage therapy range were used for the irradiation of experimental samples. In addition, radiation-induced processes of formation of silver nanoparticles in AgNO-PVA gels and in free standing AgNOPVA films, also containing some additional solvents, namely glycerol, ethanol, and isopropanol, have been investigated, with the aim to apply the developed composites for medical dosimetry purposes. A simple and environmentally friendly method for the formation of free-standing AgPVA films at room temperature was proposed and realized for preparing AgPVA films for investigation. Radiation-induced synthesis of silver nanoparticles in AgPVA composites was investigated, analyzing LPSR-based UV-VIS spectral changes to the irradiated films with respect to irradiation doses, and dose-related tendencies were also evaluated. It was shown that AgPVA films were more sensitive for detection of doses from the interval 0-1.0 Gy, thus indicating potential application of AgPVA films for dosimetry purposes.
聚合物凝胶和薄膜因其与生物组织近乎等同，是医学应用中最具前景的未来剂量测定工具之一。聚合物剂量凝胶的应用受到剂量读出方法的灵敏度和剂量凝胶特性的限制。为正交电压治疗单元输送到靶区的剂量进行登记找到合适的剂量计是一项挑战。将富含金属颗粒的聚合物复合材料应用于X射线治疗中的剂量登记可能是一个巧妙的解决方案，特别是如果涉及探索不同物理现象优势的最新剂量读取技术。在这项工作中，使用正交电压治疗范围内的X射线对实验样品进行辐照。此外，还研究了在含有一些额外溶剂（即甘油、乙醇和异丙醇）的AgNO-PVA凝胶和独立的AgNO-PVA薄膜中辐射诱导银纳米颗粒形成的过程，目的是将开发的复合材料应用于医学剂量测定。提出并实现了一种在室温下制备独立AgPVA薄膜的简单且环保的方法，用于制备用于研究的AgPVA薄膜。研究了AgPVA复合材料中辐射诱导的银纳米颗粒合成，分析了基于LPSR的紫外-可见光谱对辐照薄膜相对于辐照剂量的变化，并评估了与剂量相关的趋势。结果表明，AgPVA薄膜对0-1.0 Gy区间的剂量检测更敏感，从而表明AgPVA薄膜在剂量测定方面的潜在应用。
