• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

LRV 共进化模式分析及病毒蛋白的进化变异性。

Analyses of -LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins.

机构信息

Life Science Research Centre, Faculty of Science, University of Ostrava, 71000 Ostrava, Czech Republic.

Zoological Institute of the Russian Academy of Sciences, 199034 St. Petersburg, Russia.

出版信息

Viruses. 2021 Nov 19;13(11):2305. doi: 10.3390/v13112305.

DOI:10.3390/v13112305
PMID:34835111
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8624691/
Abstract

spp. are important pathogens causing a vector-borne disease with a broad range of clinical manifestations from self-healing ulcers to the life-threatening visceral forms. Presence of (LRV) confers survival advantage to these parasites by suppressing anti-leishmanial immunity in the vertebrate host. The two viral species, LRV1 and LRV2 infect species of the subgenera respectively. In this work we investigated co-phylogenetic patterns of leishmaniae and their viruses on a small scale (LRV2 in ) and demonstrated their predominant coevolution, occasionally broken by intraspecific host switches. Our analysis of the two viral genes, encoding the capsid and RNA-dependent RNA polymerase (RDRP), revealed them to be under the pressure of purifying selection, which was considerably stronger for the former gene across the whole tree. The selective pressure also differs between the LRV clades and correlates with the frequency of interspecific host switches. In addition, using experimental (capsid) and predicted (RDRP) models we demonstrated that the evolutionary variability across the structure is strikingly different in these two viral proteins.

摘要

种是引起一种具有广泛临床表现的虫媒病的重要病原体，从自愈性溃疡到危及生命的内脏形式。（LRV）的存在通过抑制脊椎动物宿主中的抗利什曼原虫免疫，为这些寄生虫提供了生存优势。这两种病毒种，LRV1 和 LRV2 分别感染亚属的物种。在这项工作中，我们在小规模上调查了利什曼原虫及其病毒的共同系统发育模式（LRV2 在 ），并证明了它们的主要共同进化，偶尔会被种内宿主转换打破。我们对编码衣壳和 RNA 依赖性 RNA 聚合酶（RDRP）的两个病毒基因进行了分析，发现它们受到纯化选择的压力，整个树中前者基因受到的选择压力要强得多。选择压力在 LRV 进化枝之间也有所不同，并与种间宿主转换的频率相关。此外，我们使用实验（衣壳）和预测（RDRP）模型证明，这两种病毒蛋白的结构跨越的进化可变性截然不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2578/8624691/79348b708dfd/viruses-13-02305-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2578/8624691/f91f7010dc39/viruses-13-02305-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2578/8624691/65b4c635b5e4/viruses-13-02305-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2578/8624691/b85b4de47d76/viruses-13-02305-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2578/8624691/0857d8749804/viruses-13-02305-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2578/8624691/c906e84397f8/viruses-13-02305-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2578/8624691/79348b708dfd/viruses-13-02305-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2578/8624691/f91f7010dc39/viruses-13-02305-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2578/8624691/65b4c635b5e4/viruses-13-02305-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2578/8624691/b85b4de47d76/viruses-13-02305-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2578/8624691/0857d8749804/viruses-13-02305-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2578/8624691/c906e84397f8/viruses-13-02305-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2578/8624691/79348b708dfd/viruses-13-02305-g006.jpg

相似文献

1
Analyses of -LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins.LRV 共进化模式分析及病毒蛋白的进化变异性。
Viruses. 2021 Nov 19;13(11):2305. doi: 10.3390/v13112305.
2
Leishmania aethiopica field isolates bearing an endosymbiontic dsRNA virus induce pro-inflammatory cytokine response.埃塞俄比亚利什曼原虫野毒株携带的内共生 dsRNA 病毒诱导促炎细胞因子反应。
PLoS Negl Trop Dis. 2014 Apr 24;8(4):e2836. doi: 10.1371/journal.pntd.0002836. eCollection 2014 Apr.
3
Elimination of LRVs Elicits Different Responses in spp.LRVs 的消除会在 spp. 中引起不同的反应。
mSphere. 2022 Aug 31;7(4):e0033522. doi: 10.1128/msphere.00335-22. Epub 2022 Aug 9.
4
Presence and diversity of Leishmania RNA virus in an old zoonotic cutaneous leishmaniasis focus, northeastern Iran: haplotype and phylogenetic based approach.伊朗东北部一个古老的人兽共患皮肤利什曼病焦点中利什曼 RNA 病毒的存在和多样性：基于单倍型和系统发育的方法。
Int J Infect Dis. 2020 Dec;101:6-13. doi: 10.1016/j.ijid.2020.08.033. Epub 2020 Sep 15.
5
Detection and molecular identification of leishmania RNA virus (LRV) in Iranian Leishmania species.伊朗利什曼原虫物种中利什曼原虫RNA病毒（LRV）的检测与分子鉴定
Arch Virol. 2016 Dec;161(12):3385-3390. doi: 10.1007/s00705-016-3044-z. Epub 2016 Sep 7.
6
Successful Isolation of Leishmania RNA Virus (LRV) from Leishmania major in a Cutaneous Leishmaniasis Focus in Central Iran: An Update on Cases.成功从伊朗中部皮肤利什曼病疫区的利什曼原虫中分离出利什曼 RNA 病毒（LRV）：病例更新。
Acta Parasitol. 2022 Sep;67(3):1290-1298. doi: 10.1007/s11686-022-00575-9. Epub 2022 Jun 30.
7
Capsid Structure of RNA Virus 1.RNA 病毒 1 的衣壳结构。
J Virol. 2021 Jan 13;95(3). doi: 10.1128/JVI.01957-20.
8
Detection of Leishmania RNA virus 2 in Leishmania species from Turkey.检测来自土耳其的利什曼原虫物种中的利什曼 RNA 病毒 2。
Trans R Soc Trop Med Hyg. 2019 Jul 1;113(7):410-417. doi: 10.1093/trstmh/trz023.
9
The complete sequence of Leishmania RNA virus LRV2-1, a virus of an Old World parasite strain.利什曼原虫RNA病毒LRV2-1（一种旧大陆寄生虫菌株的病毒）的完整序列。
Virology. 1995 Sep 10;212(1):84-90. doi: 10.1006/viro.1995.1456.
10
The First Non-LRV RNA Virus in .首个非 LRV RNA 病毒在... 中发现。
Viruses. 2020 Feb 2;12(2):168. doi: 10.3390/v12020168.

引用本文的文献

1
First report of Leishmania RNA virus 2 and its high genetic diversity in cutaneous leishmaniasis cases from Ilam Province, Iran.利什曼原虫RNA病毒2在伊朗伊拉姆省皮肤利什曼病病例中的首次报告及其高度遗传多样性
BMC Med Genomics. 2025 Aug 21;18(1):135. doi: 10.1186/s12920-025-02198-1.
2
A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus.一种新型巴西利什曼原虫携带的不是全病毒，而是布尼亚病毒。
PLoS Negl Trop Dis. 2024 Dec 27;18(12):e0012767. doi: 10.1371/journal.pntd.0012767. eCollection 2024 Dec.
3
Exploring the significant genetic diversity of Iranian isolates of Leishmania RNA virus 2 using whole genome sequence analysis.

本文引用的文献

1
Highly accurate protein structure prediction with AlphaFold.利用 AlphaFold 进行高精度蛋白质结构预测。
Nature. 2021 Aug;596(7873):583-589. doi: 10.1038/s41586-021-03819-2. Epub 2021 Jul 15.
2
Reproduction in Trypanosomatids: Past and Present.锥虫的繁殖：过去与现在
Biology (Basel). 2021 May 27;10(6):471. doi: 10.3390/biology10060471.
3
The Maze Pathway of Coevolution: A Critical Review over the and Its Endosymbiotic History.共生进化的“迷阵”路径：对古细菌及其内共生历史的批判性回顾。
利用全基因组序列分析探索伊朗利什曼原虫RNA病毒2分离株的显著遗传多样性。
BMC Infect Dis. 2024 Dec 18;24(1):1407. doi: 10.1186/s12879-024-10194-6.
4
Epidemiology and Genetic Characterization of RNA Virus in () spp. Isolates from Cutaneous Leishmaniasis Endemic Areas in Panama.巴拿马皮肤利什曼病流行地区()物种分离株中RNA病毒的流行病学和基因特征
Microorganisms. 2024 Jun 27;12(7):1317. doi: 10.3390/microorganisms12071317.
5
Identification of diverse RNA viruses in flagellates (Euglenozoa: Trypanosomatidae: Blastocrithidiinae).在鞭毛虫（眼虫纲：锥虫科：芽殖短膜虫亚科）中鉴定多种RNA病毒。
Virus Evol. 2024 May 4;10(1):veae037. doi: 10.1093/ve/veae037. eCollection 2024.
6
Diversity and dissemination of viruses in pathogenic protozoa.致病原生动物中的病毒多样性和传播。
Nat Commun. 2023 Dec 15;14(1):8343. doi: 10.1038/s41467-023-44085-2.
7
Exploring Host-Specificity: Untangling the Relationship between () Species and Its Endosymbiont 1.探索宿主特异性：解析（）物种与其内共生体之间的关系 1。 （注：原文括号处内容缺失）
Microorganisms. 2023 Sep 12;11(9):2295. doi: 10.3390/microorganisms11092295.
8
First report of putative Leishmania RNA virus 2 (LRV2) in Leishmania infantum strains from canine and human visceral leishmaniasis cases in the southeast of Brazil.巴西东南部犬内脏利什曼病和人内脏利什曼病病例中利什曼原虫 RNA 病毒 2（LRV2）的首次报告。
Mem Inst Oswaldo Cruz. 2023 Sep 18;118:e230071. doi: 10.1590/0074-02760230071. eCollection 2023.
9
Diversity of RNA viruses in the cosmopolitan monoxenous trypanosomatid Leptomonas pyrrhocoris.在世界性单性寄生的锥虫 Leptomonas pyrrhocoris 中 RNA 病毒的多样性。
BMC Biol. 2023 Sep 12;21(1):191. doi: 10.1186/s12915-023-01687-y.
10
Kinetoplast Genome of spp. Is under Strong Purifying Selection.锥虫属物种的动质体基因组处于强烈的纯化选择之下。
Trop Med Infect Dis. 2023 Jul 27;8(8):384. doi: 10.3390/tropicalmed8080384.
Genes (Basel). 2021 Apr 27;12(5):657. doi: 10.3390/genes12050657.
4
Catalase impairs development and virulence.过氧化氢酶损害发育和毒力。
Virulence. 2021 Dec;12(1):852-867. doi: 10.1080/21505594.2021.1896830.
5
Models in parasite and pathogen evolution: Genomic analysis reveals predominant clonality and progressive evolution at all evolutionary scales in parasitic protozoa, yeasts and bacteria.寄生虫和病原体进化中的模型：基因组分析揭示了寄生原生动物、酵母和细菌在所有进化尺度上的主要克隆性和渐进进化。
Adv Parasitol. 2021;111:75-117. doi: 10.1016/bs.apar.2020.12.001. Epub 2021 Jan 11.
6
Alignment of Biological Sequences with Jalview.使用 Jalview 进行生物序列比对。
Methods Mol Biol. 2021;2231:203-224. doi: 10.1007/978-1-0716-1036-7_13.
7
Capsid Structure of RNA Virus 1.RNA 病毒 1 的衣壳结构。
J Virol. 2021 Jan 13;95(3). doi: 10.1128/JVI.01957-20.
8
Database resources of the National Center for Biotechnology Information.国家生物技术信息中心数据库资源。
Nucleic Acids Res. 2021 Jan 8;49(D1):D10-D17. doi: 10.1093/nar/gkaa892.
9
Viruses of protozoan parasites and viral therapy: Is the time now right?原生动物寄生虫病毒与病毒疗法：现在是否时机已到？
Virol J. 2020 Sep 29;17(1):142. doi: 10.1186/s12985-020-01410-1.
10
Presence and diversity of Leishmania RNA virus in an old zoonotic cutaneous leishmaniasis focus, northeastern Iran: haplotype and phylogenetic based approach.伊朗东北部一个古老的人兽共患皮肤利什曼病焦点中利什曼 RNA 病毒的存在和多样性：基于单倍型和系统发育的方法。
Int J Infect Dis. 2020 Dec;101:6-13. doi: 10.1016/j.ijid.2020.08.033. Epub 2020 Sep 15.