• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

孕激素对激素替代治疗中血脂的影响。

The effects of progesterones on blood lipids in hormone replacement therapy.

机构信息

Guizhou Provincial Center for Drug Reevaluation, Guiyang, Guizhou, 550001, People's Republic of China.

Department of Obstetrics and Gynecology, Guizhou Provincial People's Hospital, NO.83, Zhongshan East Road, Guiyang, Guizhou, 550002, People's Republic of China.

出版信息

Lipids Health Dis. 2017 Nov 21;16(1):219. doi: 10.1186/s12944-017-0612-5.

DOI:10.1186/s12944-017-0612-5
PMID:29157280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5697110/
Abstract

The safety of progestogens as a class has drawn much attention after the publication of data from the Women's Health Initiative (WHI) trial, particularly with respect to cardiovascular disease. Depending on the chemical structure, pharmacokinetics, receptor affinity and potency of action, progestogens have a divergent range of properties that may translate to very different clinical effects. The purpose of this review is to describe the role of varied progestogens in hormone replacement therapy (HRT), especially focusing on blood lipids, which are the most important parameters for assessing cardiovascular disease risk.

摘要

孕激素作为一类药物的安全性在《女性健康倡议（WHI）试验》数据公布后引起了广泛关注，尤其是在心血管疾病方面。根据化学结构、药代动力学、受体亲和力和作用效力，孕激素具有不同的性质，这可能转化为非常不同的临床效果。本综述的目的是描述不同孕激素在激素替代疗法（HRT）中的作用，特别是重点关注血脂，这是评估心血管疾病风险的最重要参数。

相似文献

1
The effects of progesterones on blood lipids in hormone replacement therapy.孕激素对激素替代治疗中血脂的影响。
Lipids Health Dis. 2017 Nov 21;16(1):219. doi: 10.1186/s12944-017-0612-5.
2
Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects.绝经后激素治疗中使用的孕激素：其药理学特性、细胞内作用和临床效果的差异。
Endocr Rev. 2013 Apr;34(2):171-208. doi: 10.1210/er.2012-1008. Epub 2012 Dec 13.
3
Hormone replacement therapy in the post-Women's Health Initiative era. Report a a meeting held in Funchal, Madeira, February 24-25, 2003.妇女健康倡议（Women's Health Initiative）时代后的激素替代疗法。2003年2月24日至25日在马德拉岛丰沙尔举行的会议报告。
Climacteric. 2003 May;6 Suppl 1:11-36.
4
Progestogens and target tissues: vascular systems.孕激素与靶组织：血管系统
Maturitas. 2009 Apr 20;62(4):356-61. doi: 10.1016/j.maturitas.2008.12.003. Epub 2009 Jan 20.
5
[Hormone replacement Up-to-date. Menopause in women and hormone replacement therapy (HRT). Indications for HRT in postmenopausal women].[激素替代疗法最新进展。女性更年期与激素替代疗法（HRT）。绝经后女性HRT的适应证]
Clin Calcium. 2007 Sep;17(9):1315-24.
6
Effect of the Women's Health Initiative study publication on hormone replacement therapy use among women who have undergone BRCA1/2 testing.妇女健康倡议研究成果的发表对已接受BRCA1/2检测的女性使用激素替代疗法的影响。
Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):157-60. doi: 10.1158/1055-9965.EPI-06-0340.
7
Comparative cardiovascular effects of different progestins in menopause.不同孕激素在绝经后对心血管系统的比较影响
Int J Fertil Womens Med. 2001 Sep-Oct;46(5):248-56.
8
Changes in pattern of use, clinical characteristics and persistence rate of hormone replacement therapy among postmenopausal women after the WHI publication.妇女健康倡议（WHI）发布后绝经后妇女激素替代疗法的使用模式、临床特征及持续率的变化
Pharmacoepidemiol Drug Saf. 2007 Jan;16(1):17-27. doi: 10.1002/pds.1273.
9
Hormone therapy following the Women's Health Initiative (WHI) study: perception of gynecologists in Brazil.妇女健康倡议（WHI）研究后的激素疗法：巴西妇科医生的看法
Minerva Ginecol. 2005 Oct;57(5):563-8.
10
Changes in utilisation of hormone replacement therapy in Australia following publication of the findings of the Women's Health Initiative.妇女健康倡议研究结果公布后澳大利亚激素替代疗法使用情况的变化
Pharmacoepidemiol Drug Saf. 2008 Sep;17(9):861-8. doi: 10.1002/pds.1605.

引用本文的文献

1
Effects of 17β estradiol on blood pressure elevation in ovariectomized rats with collagen-induced arthritis via modulation of oxidative stress, inflammation, fibrosis, and apoptosis in the aorta involving TLR4/NOX4/NF-kβ and TGFβ1/fibronectin/α-SMA pathways.17β-雌二醇通过调节主动脉中的氧化应激、炎症、纤维化和凋亡（涉及TLR4/NOX4/NF-κβ和TGFβ1/纤连蛋白/α-SMA途径）对胶原诱导性关节炎去卵巢大鼠的血压升高产生影响。
Naunyn Schmiedebergs Arch Pharmacol. 2024 Dec 19. doi: 10.1007/s00210-024-03700-9.
2
Effectiveness of low dose cyproterone acetate compared to standard dose in feminizing hormone treatment: a single institutional retrospective pilot study.低剂量醋酸环丙孕酮与标准剂量在女性化激素治疗中的有效性比较：一项单机构回顾性试点研究。
Sex Med. 2024 Sep 21;12(4):qfae063. doi: 10.1093/sexmed/qfae063. eCollection 2024 Aug.
3
Lipoprotein(a) and cardiovascular disease.脂蛋白(a)与心血管疾病。
Biochem J. 2024 Oct 2;481(19):1277-1296. doi: 10.1042/BCJ20240037.
4
Multi-faceted Anti-obesity Effects of N-Methyl-D-Aspartate (NMDA) Receptor Modulators: Central-Peripheral Crosstalk.N-甲基-D-天冬氨酸（NMDA）受体调节剂的多方面抗肥胖作用：中枢-外周串扰。
J Mol Neurosci. 2024 Jan 19;74(1):13. doi: 10.1007/s12031-023-02178-z.
5
The Impact of Menopause on Cardiovascular Aging: A Comprehensive Review of Androgen Influences.更年期对心血管衰老的影响：雄激素影响的综合综述
Cureus. 2023 Aug 16;15(8):e43569. doi: 10.7759/cureus.43569. eCollection 2023 Aug.
6
Type 1 Diabetes and the Menstrual Cycle: Where/How Does Exercise Fit in?1 型糖尿病与月经周期：运动该如何融入其中？
Int J Environ Res Public Health. 2023 Feb 4;20(4):2772. doi: 10.3390/ijerph20042772.
7
Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation.健康与疾病状态下高密度脂蛋白与内皮细胞之间的相互作用：对性别依赖性调节的见解
Front Cardiovasc Med. 2022 Oct 6;9:989428. doi: 10.3389/fcvm.2022.989428. eCollection 2022.
8
Progesterone in gender-affirming therapy of trans women.孕酮在跨性别女性性别肯定治疗中的应用
World J Biol Chem. 2022 May 27;13(3):66-71. doi: 10.4331/wjbc.v13.i3.66.
9
The effectiveness of desogestrel for endometrial protection in women with abnormal uterine bleeding-ovulatory dysfunction: a non-inferiority randomized controlled trial.去氧孕烯用于排卵功能障碍性异常子宫出血患者子宫内膜保护的有效性：一项非劣效性随机对照试验。
Sci Rep. 2022 Jan 31;12(1):1662. doi: 10.1038/s41598-022-05578-0.
10
New insights into the functions of progesterone receptor (PR) isoforms and progesterone signaling.孕酮受体（PR）亚型功能及孕酮信号传导的新见解。
Am J Cancer Res. 2021 Nov 15;11(11):5214-5232. eCollection 2021.

本文引用的文献

1
Effect of Half-dose and Standard-dose Conjugated Equine Estrogens Combined with Natural Progesterone or Dydrogesterone on Components of Metabolic Syndrome in Healthy Postmenopausal Women: A Randomized Controlled Trial.半剂量与标准剂量结合马雌激素联合天然孕酮或地屈孕酮对健康绝经后女性代谢综合征组分的影响：一项随机对照试验
Chin Med J (Engl). 2016 Dec 5;129(23):2773-2779. doi: 10.4103/0366-6999.194646.
2
Progestogens in menopausal hormone therapy.绝经激素治疗中的孕激素
Prz Menopauzalny. 2015 Jun;14(2):134-43. doi: 10.5114/pm.2015.52154. Epub 2015 Jun 22.
3
Effects of estradiol-drospirenone on menopausal symptoms, lipids and bone turnover in Chinese women.雌二醇 - 屈螺酮对中国女性更年期症状、血脂及骨转换的影响
Climacteric. 2015 Apr;18(2):214-8. doi: 10.3109/13697137.2014.978753. Epub 2015 Jan 2.
4
Systemic delivery of estradiol, but not testosterone or progesterone, alters very low density lipoprotein-triglyceride kinetics in postmenopausal women.雌二醇经全身给药后会改变绝经后女性极低密度脂蛋白甘油三酯的动力学，而睾酮或孕酮则不会。
J Clin Endocrinol Metab. 2014 Jul;99(7):E1306-10. doi: 10.1210/jc.2013-4470. Epub 2014 Apr 2.
5
Progesterone therapy, endothelial function and cardiovascular risk factors: a 3-month randomized, placebo-controlled trial in healthy early postmenopausal women.孕激素治疗、血管内皮功能与心血管危险因素：健康早绝经后妇女 3 个月随机、安慰剂对照试验。
PLoS One. 2014 Jan 21;9(1):e84698. doi: 10.1371/journal.pone.0084698. eCollection 2014.
6
The "newer" progestogens and postmenopausal hormone therapy (HRT).“较新”的孕激素和绝经后激素治疗（HRT）。
J Steroid Biochem Mol Biol. 2014 Jul;142:48-51. doi: 10.1016/j.jsbmb.2013.12.003. Epub 2013 Dec 12.
7
Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects.绝经后激素治疗中使用的孕激素：其药理学特性、细胞内作用和临床效果的差异。
Endocr Rev. 2013 Apr;34(2):171-208. doi: 10.1210/er.2012-1008. Epub 2012 Dec 13.
8
Effects of micronized progesterone added to non-oral estradiol on lipids and cardiovascular risk factors in early postmenopause: a clinical trial.米诺孕素联合非口服雌激素对早绝经后妇女血脂及心血管危险因素的影响：一项临床试验。
Lipids Health Dis. 2012 Oct 9;11:133. doi: 10.1186/1476-511X-11-133.
9
The effects of 17β-estradiol plus drospirenone on anthropometric and biochemical measures of adiposity in menopausal women.17β-雌二醇加屈螺酮对绝经后妇女人体测量学和脂肪肥胖生化指标的影响。
Arch Gynecol Obstet. 2012 Nov;286(5):1233-9. doi: 10.1007/s00404-012-2437-9. Epub 2012 Jul 13.
10
Dydrogesterone does not reverse the cardiovascular benefits of percutaneous estradiol.地屈孕酮不能逆转经皮雌二醇的心血管获益。
Climacteric. 2013 Feb;16(1):54-61. doi: 10.3109/13697137.2012.672843. Epub 2012 May 28.