Mezhal Fatima, Oulhaj Abderrahim, Abdulle Abdishakur, AlJunaibi Abdulla, Alnaeemi Abdulla, Ahmad Amar, Leinberger-Jabari Andrea, Al Dhaheri Ayesha S, Tuzcu E Murat, AlZaabi Eiman, Al-Maskari Fatma, Alanouti Fatme, Alameri Fayza, Alsafar Habiba, Alblooshi Hamad, Alkaabi Juma, Wareth Laila Abdel, Aljaber Mai, Kazim Marina, Weitzman Micheal, Al-Houqani Mohammad, Ali Mohammad Hag, Oumeziane Naima, El-Shahawy Omar, Al-Rifai Rami H, Scherman Scott, Shah Syed M, Loney Tom, Almahmeed Wael, Idaghdour Youssef, Ahmed Luai A, Ali Raghib
Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, UAE.
Department of Epidemiology and Public Health, College of Medicine and Health Sciences, Khalifa University of Sciences and Technology, Abu Dhabi, UAE.
Diabetol Metab Syndr. 2021 Nov 27;13(1):140. doi: 10.1186/s13098-021-00758-w.
Similar to other non-communicable diseases (NCDs), people who develop cardiovascular disease (CVD) typically have more than one risk factor. The clustering of cardiovascular risk factors begins in youth, early adulthood, and middle age. The presence of multiple risk factors simultaneously has been shown to increase the risk for atherosclerosis development in young and middle-aged adults and risk of CVD in middle age.
This study aimed to address the interrelationship of CVD risk factors and their accumulation in a large sample of young adults in the United Arab Emirates (UAE).
Baseline data was drawn from the UAE Healthy Future Study (UAEHFS), a volunteer-based multicenter study that recruits Emirati nationals. Data of participants aged 18 to 40 years was used for cross-sectional analysis. Demographic and health information was collected through self-reported questionnaires. Anthropometric data and blood pressure were measured, and blood samples were collected.
A total of 5126 participants were included in the analysis. Comorbidity analyses showed that dyslipidemia and obesity co-existed with other cardiometabolic risk factors (CRFs) more than 70% and 50% of the time, respectively. Multivariate logistic regression analysis of the risk factors with age and gender showed that all risk factors were highly associated with each other. The strongest relationship was found with obesity; it was associated with four-fold increase in the odds of having central obesity [adjusted OR 4.70 (95% CI (4.04-5.46)], and almost three-fold increase odds of having abnormal glycemic status [AOR 2.98 (95% (CI 2.49-3.55))], hypertension (AOR 3.03 (95% CI (2.61-3.52))] and dyslipidemia [AOR 2.71 (95% CI (2.32-3.15)]. Forty percent of the population accumulated more than 2 risk factors, and the burden increased with age.
In this young population, cardiometabolic risk factors are highly prevalent and are associated with each other, therefore creating a heavy burden of risk factors. This forecasts an increase in the burden of CVD in the UAE. The robust longitudinal design of the UAEHFS will enable researchers to understand how risk factors cluster before disease develops. This knowledge will offer a novel approach to design group-specific preventive measures for CVD development.
与其他非传染性疾病（NCDs）类似，患心血管疾病（CVD）的人通常有不止一种风险因素。心血管风险因素的聚集始于青年期、成年早期和中年期。已表明同时存在多种风险因素会增加年轻和中年成年人患动脉粥样硬化的风险以及中年患心血管疾病的风险。
本研究旨在探讨阿联酋（UAE）大量年轻成年人中心血管疾病风险因素的相互关系及其聚集情况。
基线数据取自阿联酋健康未来研究（UAEHFS），这是一项基于志愿者的多中心研究，招募阿联酋国民。对18至40岁参与者的数据进行横断面分析。通过自我报告问卷收集人口统计学和健康信息。测量人体测量数据和血压，并采集血样。
共有5126名参与者纳入分析。合并症分析表明，血脂异常和肥胖分别在超过70%和50%的时间里与其他心脏代谢风险因素（CRFs）共存。对风险因素与年龄和性别的多变量逻辑回归分析表明，所有风险因素彼此高度相关。与肥胖的关系最为密切；它与中心性肥胖几率增加四倍相关[调整后的比值比（OR）为4.70（95%置信区间（CI）（4.04 - 5.46））]，与血糖状态异常几率增加近三倍相关[调整后的比值比（AOR）为2.98（95%（CI）2.49 - 3.55）]，与高血压（AOR为3.03（95% CI（2.61 - 3.52））]和血脂异常[ AOR为2.71（95% CI（2.32 - 3.15））]相关。40%的人群积累了超过2种风险因素，且负担随年龄增加。
在这个年轻人群中，心脏代谢风险因素高度普遍且相互关联，因此造成了沉重的风险因素负担。这预示着阿联酋心血管疾病负担将增加。UAEHFS强大的纵向设计将使研究人员能够了解疾病发生前风险因素是如何聚集的。这些知识将为设计针对特定群体的心血管疾病预防措施提供新方法。
