Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China.
Front Cell Infect Microbiol. 2021 Nov 9;11:703126. doi: 10.3389/fcimb.2021.703126. eCollection 2021.
Chronic urticaria (CU) is a chronic inflammatory skin disease associated with Th2 immune response. The two most common subtypes of CU, i.e., chronic spontaneous urticaria and symptomatic dermographism (CSD), often coexist. However, the pathogenesis of CSD is still unclear. Gut microbiota plays an important role in immune-related inflammatory diseases. The purpose of this study was to explore the correlation between gut microbiota and CSD.
A case-control study was conducted on CSD patients as well as gender- and age-matched normal controls (NCs). The 16S ribosomal DNA sequencing of fecal samples was used to detect the gut microbiota of all subjects. QPCR was used to further verify the species with differences between the two groups.
The alpha diversity of gut microbiota decreased in CSD patients, accompanied by significant changes of the structure of gut microbiota. and decreased significantly in CSD patients and had a potential diagnostic value for CSD according to receiver operating characteristic curve (ROC) analysis. and were found to be positively correlated with the duration of CSD, while was positively correlated with the dermatology life quality index (DLQI).
The gut microbiota of CSD patients is imbalanced. and are the gut microbiota biomarkers in CSD.
慢性荨麻疹（CU）是一种与 Th2 免疫反应相关的慢性炎症性皮肤病。CU 的两种最常见亚型，即慢性自发性荨麻疹和症状性皮肤划痕症（CSD），常同时存在。然而，CSD 的发病机制仍不清楚。肠道微生物群在免疫相关炎症性疾病中发挥着重要作用。本研究旨在探讨肠道微生物群与 CSD 之间的相关性。
对 CSD 患者以及性别和年龄匹配的正常对照（NC）进行病例对照研究。使用粪便样本的 16S 核糖体 DNA 测序来检测所有受试者的肠道微生物群。QPCR 用于进一步验证两组之间存在差异的物种。
CSD 患者的肠道微生物群 α 多样性降低，同时肠道微生物群结构发生显著变化。CSD 患者中 和 显著减少，且根据受试者工作特征曲线（ROC）分析，具有诊断 CSD 的潜在价值。 和 与 CSD 的持续时间呈正相关，而 与皮肤病生活质量指数（DLQI）呈正相关。
CSD 患者的肠道微生物群失衡。 和 是 CSD 的肠道微生物群生物标志物。
