Zhang Wenqian, Hu Jungen, Huang Yizhou, Wu Chenyu, Xie Huiqi
Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, Med-X Center for Materials, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Burns Trauma. 2021 Nov 26;9:tkab039. doi: 10.1093/burnst/tkab039. eCollection 2021.
As an emerging type of adult stem cell featuring non-invasive acquisition, urine-derived stem cells (USCs) have shown great potential for applications in tissue engineering and regenerative medicine. With a growing amount of research on the topic, the effectiveness of USCs in various disease models has been shown and the underlying mechanisms have also been explored, though many aspects still remain unclear. In this review, we aim to provide an up-to-date overview of the biological characteristics of USCs and their applications in skin, bone and articular cartilage repair. In addition to the identification procedure of USCs, we also summarize current knowledge of the underlying repair mechanisms and application modes of USCs. Potential concerns and perspectives have also been summarized.
作为一种具有非侵入性获取特点的新型成体干细胞，尿液来源干细胞（USCs）在组织工程和再生医学应用中显示出巨大潜力。随着对该主题研究的不断增加，USCs在各种疾病模型中的有效性已得到证实，其潜在机制也已得到探索，尽管许多方面仍不清楚。在本综述中，我们旨在提供USCs生物学特性及其在皮肤、骨骼和关节软骨修复中应用的最新概述。除了USCs的鉴定程序外，我们还总结了USCs潜在修复机制和应用模式的现有知识。还总结了潜在的关注点和前景。
