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南非青少年艾滋病毒流行率的趋势和相关因素:来自 2008、2012 和 2017 年南非全国艾滋病毒流行率、发病率和行为调查的证据。

Trends and correlates of HIV prevalence among adolescents in South Africa: evidence from the 2008, 2012 and 2017 South African National HIV Prevalence, Incidence and Behaviour surveys.

机构信息

Human and Social Capabilities Research Division, Human Sciences Research Council, Pretoria, South Africa.

Biostatistics Unit, South African Medical Research Council, Durban, South Africa.

出版信息

AIDS Res Ther. 2021 Dec 14;18(1):97. doi: 10.1186/s12981-021-00422-3.

Abstract

BACKGROUND

Adolescents are at increased risk of HIV infection compared to other age groups. There is an urgent need for strategic information that will inform programmes to reduce risk and vulnerability to HIV and reverse the pattern of increasing HIV infection as they transition to adulthood. This paper analysed trends and factors associated with HIV prevalence among adolescents in South Africa using the national HIV population-based household surveys conducted in 2008, 2012 and 2017.

METHODS

All three surveys used a multistage cross-sectional design. A trend analysis was conducted to assess the differences in HIV prevalence and covariates overtime using P-trend Chi-squared statistic. Univariate and multivariate logistic regression models were used to determine factors associated with HIV prevalence.

RESULTS

Overall there was a significant increase in HIV prevalence among adolescents aged 12-19 years from 3.0% (n = 2892) in 2008 to 3.2% (n = 4829) in 2012 and 4.1% (n = 3937) in 2017 (p = 0.031). The odds of being HIV positive among adolescents aged 12-19 years was significantly higher among females [AOR = 2.24; 95% CI (1.73-2.91); p < 0.001] than males, those residing in KwaZulu-Natal province [AOR = 2.01; 95% CI (1.-3.99); p = 0.027] than Northern Cape, and those who did not attend an educational institution and were unemployed [AOR = 2.66; 95% CI (1.91-3.67); p < 0.001] compared to those attending an educational institution. The odds were significantly lower among Whites [AOR = 0.29; 95% CI (0.09-0.93); p = 0.037], Coloureds [AOR = 0.21; 95% CI (0.11-0.37); p ≤ 0.001] and Indian/Asian [AOR = 0.08; 95% CI (0.02-0.34); p = 0.001] population groups than Black Africans.

CONCLUSION

The observed increasing trend and gender disparities in HIV prevalence suggests an urgent need for age appropriate and gender specific HIV interventions tailored and targeted at identified drivers of HIV infection among adolescents.

摘要

背景

与其他年龄组相比,青少年感染艾滋病毒的风险更高。迫切需要有战略性的信息,以便制定方案,降低艾滋病毒风险和脆弱性,并扭转随着青少年向成年过渡艾滋病毒感染不断增加的趋势。本文利用 2008 年、2012 年和 2017 年全国艾滋病毒人群家庭调查,分析了南非青少年艾滋病毒流行的趋势和相关因素。

方法

所有三项调查均采用多阶段横断面设计。使用 P-趋势卡方检验评估随时间变化的艾滋病毒流行率和协变量的差异。使用单变量和多变量逻辑回归模型确定与艾滋病毒流行率相关的因素。

结果

12-19 岁青少年的艾滋病毒流行率总体呈上升趋势,从 2008 年的 3.0%(n=2892)上升到 2012 年的 3.2%(n=4829),再到 2017 年的 4.1%(n=3937)(p=0.031)。与男性相比,12-19 岁青少年感染艾滋病毒的几率显著更高,女性(AOR=2.24;95%CI(1.73-2.91);p<0.001),居住在夸祖鲁-纳塔尔省(AOR=2.01;95%CI(1.00-3.99);p=0.027)比北开普省,未接受教育且失业(AOR=2.66;95%CI(1.91-3.67);p<0.001)比接受教育的青少年。与黑人相比,白人(AOR=0.29;95%CI(0.09-0.93);p=0.037)、混血儿(AOR=0.21;95%CI(0.11-0.37);p≤0.001)和印度/亚洲人(AOR=0.08;95%CI(0.02-0.34);p=0.001)感染艾滋病毒的几率显著较低。

结论

观察到艾滋病毒流行率呈上升趋势和性别差异表明,迫切需要针对青少年艾滋病毒感染的特定驱动因素,制定适合年龄和性别的艾滋病毒干预措施。

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