Farahmand Mohammad, Tavakoli Ahmad, Ghorbani Saied, Monavari Seyed Hamidreza, Kiani Seyed Jalal, Minaeian Sara
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Asian J Transfus Sci. 2021 Jul-Dec;15(2):212-222. doi: 10.4103/ajts.ajts_185_20. Epub 2021 Nov 1.
Human parvovirus B19 (B19V) is one of the blood-borne viruses. The virus can be transmitted to susceptible individuals by blood or blood products. The virus is not associated with significant disease in general population, while people with underlying problems such as immunodeficiency can cause anemia and arthritis. The current systematic review and meta-analysis aimed to estimate the overall prevalence of B19V DNA, anti-B19V IgG, and anti-B19V IgM antibodies in blood donors worldwide.
A systematic search was carried out in online databases for relevant studies from inception until March 30, 2019. Study selection was performed based on predesigned eligibility criteria. The proportion of B19V DNA, anti-B19V IgG, and anti-B19V IgM antibodies were pooled using the inverse variance method. All statistical analyses were performed using the R version 3.5.3, package "meta."
According to the random-effects model, the pool prevalence of B19V DNA, anti-B19V IgM, and anti-B19V IgG among blood donors was calculated to be 0.4% (95% confidence interval [CI] =0.3%-0.6%), 2.2% (95% CI = 1.3%-3.7%), and 50.1% (95% CI = 43.1%-57.1%), respectively.
For the transmission of B19V through blood, the presence of the virus genome is required, and the present study showed that the prevalence of the virus genome in blood donors is <1%. Therefore, there is no need to screen donated blood for B19V infection.
人细小病毒B19（B19V）是血源病毒之一。该病毒可通过血液或血液制品传播给易感个体。在一般人群中，该病毒通常不会引发严重疾病，但对于存在免疫缺陷等潜在问题的人，可能会导致贫血和关节炎。当前的系统评价和荟萃分析旨在估计全球献血者中B19V DNA、抗B19V IgG和抗B19V IgM抗体的总体流行率。
在在线数据库中进行系统检索，纳入自数据库建立至2019年3月30日的相关研究。根据预先设计的纳入标准进行研究筛选。采用逆方差法汇总B19V DNA、抗B19V IgG和抗B19V IgM抗体的比例。所有统计分析均使用R 3.5.3版本及“meta”软件包进行。
根据随机效应模型，计算得出献血者中B19V DNA、抗B19V IgM和抗B19V IgG的合并流行率分别为0.4%（95%置信区间[CI]=0.3%-0.6%）、2.2%（95%CI=1.3%-3.7%）和50.1%（95%CI=43.1%-57.1%）。
对于B19V通过血液传播而言，病毒基因组的存在是必要条件，本研究表明献血者中病毒基因组的流行率<1%。因此，无需对献血进行B19V感染筛查。
