Bioinformatics/High Throughput Analysis, Faculty of Mathematics and Computer Science, Friedrich Schiller University Jena, Jena, Germany.
FLI Leibniz Institute for Age Research, Jena, Germany.
Aging (Albany NY). 2021 Dec 19;13(24):25694-25716. doi: 10.18632/aging.203788.
The circadian clock system influences the biology of life by establishing circadian rhythms in organisms, tissues, and cells, thus regulating essential biological processes based on the day/night cycle. Circadian rhythms change over a lifetime due to maturation and aging, and disturbances in the control of the circadian system are associated with several age-related pathologies. However, the impact of chronobiology and the circadian system on healthy organ and tissue aging remains largely unknown. Whether aging-related changes of the circadian system's regulation follow a conserved pattern across different species and tissues, hence representing a common driving force of aging, is unclear. Based on a cross-sectional transcriptome analysis covering 329 RNA-Seq libraries, we provide indications that the circadian system is subjected to aging-related gene alterations shared between evolutionarily distinct species, such as , , , and . We discovered differentially expressed genes by comparing tissue-specific transcriptional profiles of mature, aged, and old-age individuals and report on six genes (, , , , , and ) of the circadian system, which show conserved aging-related expression patterns in four organs of the species examined. Our results illustrate how the circadian system and aging might influence each other in various tissues over a long lifespan and conceptually complement previous studies tracking short-term diurnal and nocturnal gene expression oscillations.
生物钟系统通过在生物体、组织和细胞中建立生物钟节律来影响生命生物学，从而根据昼夜周期调节基本的生物过程。生物钟节律会随着成熟和衰老而发生变化，并且生物钟系统控制的紊乱与几种与年龄相关的病理学有关。然而，生物钟和生物钟系统对健康器官和组织衰老的影响在很大程度上仍然未知。随着年龄的增长，生物钟系统的调节是否会遵循不同物种和组织之间的保守模式，从而代表衰老的共同驱动力，目前尚不清楚。基于涵盖 329 个 RNA-Seq 文库的横截面转录组分析，我们提供的迹象表明，生物钟系统受到不同物种之间共享的与年龄相关的基因改变的影响，例如、、、和。我们通过比较成熟、衰老和老年个体的组织特异性转录谱来比较差异表达基因，并报告生物钟系统中的六个基因（、、、、和），它们在检查的四个物种的四个器官中表现出保守的与年龄相关的表达模式。我们的研究结果说明了生物钟系统和衰老如何在长时间的寿命中在各种组织中相互影响，并在概念上补充了之前跟踪短期昼夜基因表达波动的研究。
